抗抑郁治疗在脑卒中功能恢复中的作用  

Preliminary survey of the effect of antidepressants on the stroke patients with depressive symptoms.

作　　者：黄延焱[1] 韩国红[1] 徐一峰[2] 贺凤凤[1] 

机构地区：[1]上海医科大学附属华山医院老年科,200040 [2]上海医科大学精神医学教研室,200040

出　　处：《上海精神医学》1999年第4期212-214,共3页Shanghai Archives of Psychiatry

摘　　要：目的 探讨脑血管意外伴抑郁症状患者应用抗抑郁药物治疗对其病程及预后的影响。方法 经CES-D筛选出伴抑郁症状的125例脑血管意外患者,随机分为两组。治疗组65名,非治疗组62名,两组在年龄,性别,神经功能缺损及CES-D评分等项目上无明显差异。治疗组予抗抑郁药物PROZAC20mgqd治疗,平均治疗时间为175±43.8天,一月及一年后再对两组进行CES-D及神经功能缺损的评定及比较。结果治疗组一月及一年后CES-D评分均有明显下降(p<0.001),神经功能恢复也明显好于非治疗组(P<0.01)。结论 脑血管意外伴抑郁症状者给予抗抑郁治疗对其病情改善和预后均有好处。Objectives: To examine the effect of antidepressants on the process and prognosis of the stroke patients with depressive symptoms. Methods: 125 stroke patients were found to have depressive symptoms by CES-D and were randomly divided into two groups: 63 patients were given PROZAC 20mg qd for six months; 62 patients were given no antidepressants. The patients were re-evaluated one month and one year after stroke. Results: The scores of CES-D test were significantly decreased in the patients receiving anti-depressants one month (p< 0.001) and one year later (p< 0.001); the neurological functions were more improved than those of patients without antidepressive drugs (P< 0.001). Conclusion: There were some advantages of giving anti-depressive drugs to the stroke patients with depressive symptoms.

关 键 词：抑郁症状 脑血管意外 抗抑郁剂 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.41[医药卫生—临床医学]