胰腺癌组织中VEGF的表达与血管计数的关系  

The relationship between expression of vascular endothelial growth factor (VEGF) and vessel count in pancreatic carcinoma.

作　　者：赵永恒[1] 纪宗正[1] 

机构地区：[1]西安医科大学第二附属医院普外科,710004

出　　处：《陕西肿瘤医学》2000年第1期12-14,共3页ShanXi Oncology Medicine

摘　　要：目的　研究血管内皮生长因子（ＶＥＧＦ）在胰腺癌组织血管形成中的作用。方法采用免疫组织化学 ＡＢＣ法研究了３３的胰腺癌标本中 ＶＥＧＦ的表达及分布，并研究了ＶＥＧＦ的表达强度与肿瘤血管计数的关系。结果（１）２２例（６６．７％）强表达ＶＥＧＦ， ８例（２４．２％）表达呈中等强度，３例（９．１％）呈弱阳性。ＶＥＧＦ在癌细胞呈胞浆内染色，肿瘤间质血管内皮细胞及瘤周正常组织中也可见 ＶＥＧＦ着色。（２）ＶＥＧＦ中等强度以上染色的病例中７例（２３．３％）血管计数不足 ２０个，弱阳性的标本中 １例计数达 １５个。（３）ＶＥＧＦ表达强度与肿瘤血管计数存在显著相关性（Ｐ＜０．０５）。结论ＶＥＧＦ在胰腺病组织血管形成过程中起重要作用，可以作为肿瘤血管抑制治疗的靶因子。Objective To investigate the role of VEGF in the angiogenesis of pancreatic carcinoma. Methods We studied the VEGF expression and dis- tribution and the relatinship between stain intensity and tumor vessel count. Results ①VEGF was strongly expressed in 22 cases (66. 7%),8 cases (24. 2%) moderately and 3 cases (9. 1 % ) weakly. VEGF stain mainly distributed in tumor cells, tumor stroma and pericancerous tissues. ② The vessel count of 7 cases stained moderately was not beyond 20, 1 case stained weakly up to 15. ③There was strong relevance between VEGF stain intensity and vessel count (P<0. 05)。Conclusion VEGF play a important role in angiogenesis of pancreatic carcinoma and can be used as target to inhibit the progress of tumor.

关 键 词：胰腺癌 血管内皮生长因子 VEGF 血管计数 

分 类 号：R735.9[医药卫生—肿瘤]