UFTM与EAP方案治疗晚期胃癌临床观察  

Observation of combination chemotherapy based on UFTM and EAP regimens in advanced gastric cancer

作　　者：刘明放[1] 罗湘江[1] 金向明[1] 居晓丹 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004 [2]浙江宁波北仑宗瑞医院,浙江宁波315806

出　　处：《陕西肿瘤医学》2000年第4期220-221,共2页ShanXi Oncology Medicine

摘　　要：目的　比较研究UFTM和EAP化疗方案治疗晚期胃癌的疗效 ,生存时间和毒副反应。方法　 5 3例晚期胃癌接受系统化疗 ,UFTM组 2 8例 ,EAP组 2 5例。结果　两组有效率 (CR +PR)分别为5 0 %和 6 0 % ,无显著性差异 (P >0 .0 5 ) ,中位生存期为 6月和 7月 ,毒副反应主要为消化道反应和骨髓抑制 ,EAP明显高于UFTM (P <0 .0 5 )。结论　两方案对晚期胃癌均有较好的疗效 ,但EAP方案毒副反应大 ,临床应用范围受到限制。Objective The aim of this study was to observe comparativelly the response rate, the survival time and the toxicity of UFTM and EAP combination chemotherapy in advanced gastric cancer.Methods The 53 cases of advanced gastric cancer were treated with systematic combination chemotherapy, 28 cases in UFTM group and 25 cases in EAP group. Results The response rate was 50% in UFTM group and 60% in EAP group. The difference in median survival period was 6 months and 7 months. The results showed the response rate and survival period in two groups were not statistically significant(P>0.05). EAP had higher toxic effect than UFTM(P<0.05). covering mainly the digestive disorder and myelosuppresion. Conclusions UFTM and EAP have higher response rate in advanced gastric cancer, respectivelly. However, EAP should be limited in clinical use, due to its toxic effect.

关 键 词：化疗 晚期胃癌 药物治疗 UFTM方案 EAP方案 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]