Ce^(3+)对细胞膜电位的影响  

Effect of Ce^(3+) on membrane potential of cells

作　　者：申治国[1] 庄志雄[1] 黄海雄[1] 张锦周[1] 张炳尧[1] 雷衡毅[2] 杨燕生[2] 

机构地区：[1]深圳市卫生防疫站,广东518020 [2]中山大学化学与化学工程学院,广州510275

出　　处：《中国卫生检验杂志》2001年第2期131-133,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家自然科学基金(29671034);广东省自然科学基金(980329)资助项目

摘　　要：采用显微荧光术研究了 Ｃｅ３＋对肝细胞和 Ｖ７９细胞质膜电位和线粒体膜电位的影响。结果表明，低浓度的 Ｃｅ３＋降低肝细胞的质膜电位，高浓度则显著降低肝细胞的质膜电位，提示 Ｃｅ３＋可使细胞质膜通透性增加；Ｃｅ３＋可增加 Ｖ７９细胞线粒体膜电位，提示 Ｃｅ３＋可增加细胞的能量供应。The effect of Ce3+ on plasma membrane potential and mitochondrial membrane potential of bepatocytes and V79 cells was studied with microfluorometry. The results showed that Ce3+ could increase the plasma potential of hepatocytes in low dose and increase the plasma potential of hepatocytes in high dose significantly. The results the showed that Ce3+ could increase the mitochondrial membrane potential of V79 cells. The results suggested that Ce3+ could enhencl the permeability of plasma membrane and increase the energysupplying of cell

关 键 词：铈 肝细胞 膜电位 显微荧光术 

分 类 号：R114[医药卫生—卫生毒理学]