口腔癌术后短期内死亡原因及DNA定量分析  

Analyses of Causes of Shot-term Post-operative Death and DNA Quantitative Analysis in Patients with Oral Cavity Carcinoma

作　　者：刘辉[1] 陆伟[1] 黄加兴[1] 

机构地区：[1]福建省肿瘤医院头颈科,福州350014

出　　处：《四川肿瘤防治》2001年第2期87-89,共3页Sichuan Journal of Cancer Control

摘　　要：目的 :通过对口腔癌短期内死亡病例的分析 ,了解死亡原因与肿瘤分期、治疗手段、病理分级、DNA定量分析的关系 ,以规范治疗 ,提高生存率。方法 :93例用平阳霉素化疗 ,总量160mg/10天 ,38例用DDP30mg、5Fu750mg连续化疗5天 ,加放射治疗DT4500cGy,26例颞浅动脉插管化疗 ,共用DDP120mg,5Fu3750mg,MTX40mg,均采用联合根治术 ,下颌切除或方块切除 ,同期手术修复105例。DNA定量分析采用真彩色图像分析系统 ,检测样本为Feulgen染色的石蜡切片。结果 :术前治疗除7例T3 、T4 稍有缩小外 ,其余原发肿瘤均缩小1/2左右。7例原发灶复发 ,1例肺部转移。DNA含量分析 ,峰值在近2倍体处 ,1例在5倍体外 ,死亡与非死亡病例的DNA含量无差异。结论 :死亡原因与分期、手术切除范围、切缘是否癌残留及综合治疗关系密切 ,同期手术整复有利于彻底切除和功能恢复 。Objective:To investigate the causes of shot term post opcrative death,by analyging the following prognostic factors tumor staging,treatment methods,pathologic grading and DNA analysis in patients with oral cavity carcinoma.Method:93 patients received pre operative chemotherapy with pingyangmycine,the total dose was 160mg/10 days.38 patients were treated with total dose of DDP 150mg,5 Fu 3750mg by continuous infusion in 5 days and concurrent radiotherapy,D T 4500 cGy26 patients were treated by transcatheter intra arterial chemotherapy via superficial temporal artery using total DDP 120mg,5 Fu 3750mg and MTX 40mg. After pre operative treatments all patients were treated with combining radical resection and among them 105 patients surgical reconstructions were done synchronously.The pathologic slices were stained with Feuglen and DNA quantity was analyzed with Tnle Muticalar Imoge Analysis System.Results:Except 7 patients with T3,T4 tumor,all patients achieved PR after neoadjuvant chemotherapy with concurrent RT.7 patients recurred locally and one patient developed pulmonary metastasis post operatively.DNA quantitative analysis found that the peaks located at diploid cells and only one caes located at penta_ploid.There was no difference of DNA quantity between survivors and died cases post operatively.Conclusion: For oral cancer patients,the causes of short term death after operation were closely correlated with disease stage,resected volume,conditions of surgical margin(residual malgnent cells(+)or(-)),and treatment method.Synchronous surgical reconstruction was beneficial for restoring oral function.The relapse of oral cancer had no relation with pathological stage and DNA quantity.

关 键 词：口腔癌 死亡因素 DNA定量分析 

分 类 号：R739.8[医药卫生—肿瘤]