羟基喜树碱、氨甲蝶呤、5-氟脲嘧啶与醛氢叶酸钙联合化疗治疗晚期肺腺癌  

Combined chemotherapy of HCPT,MTX,5-Fu and Leucovorin for advanced lung adenocarcinoma

作　　者：刘巍[1] 冯威健[1] 杨瑞合[1] 翟宝娥[1] 姜达[1] 

机构地区：[1]河北医科大学第四医院(河北省肿瘤医院)肿瘤内科,石家庄市050011

出　　处：《河北医药》2001年第4期248-249,共2页Hebei Medical Journal

摘　　要：目的　本文观察了羟基喜树碱 (HCPT)、氨甲蝶呤 (MTX)、5 氟脲嘧啶 (5 Fu)和醛氢叶酸钙(LV)联合方案治疗晚期肺腺癌的疗效及毒副作用。方法　化疗方案为羟基喜树碱 8mg m2 静脉滴注 ,第 1～ 5天 ;氨甲蝶呤 10 0mg静脉推注 ,第 1日 ;醛氢叶酸钙 15 0mg m2 第 2～ 4天 ,静脉滴注 ;5 氟脲嘧啶5 0 0mg m2 静脉滴注 ,第 1～ 5天 ;2 8d为 1周期 ,连用 2个周期以上。结果　HMLF方案治疗晚期肺腺癌5 1例 ,总有效率 49% ,1年生存率 41% ,中位生存期为 11个月。主要毒副作用为轻度的血液和消化道反应。Objective The therapeutic effects and side effects of combined chemotherapy of HCPT, MTX, LV and 5 Fu for Advanced Lung adenocarcinoma were evaluated.Methods Chemotherapy regimen consisted of HCPT 8 mg/m 2 IV gtt l～5 d, MTX 100 mg IV dl, and Leucovorin 150 mg/m 2 IV gtt 2～4 d, 5 Fu 500 mg/m 2 IV gtt 1～5 d. The cycle was repeated every 4 weeks and 2 cycles were given as 1 course.Results Total 51 cases was treated. Overall CR+PR was 49% .One year survival rate was 41%, Main median survival interval was 11 months. The major side effects were bone marrow suppression and gastrointestinal tract side effects.Conclusion The combined chemotherapy regimen consisting of HCPT was benefit for advanced lung adenocarcinoma.

关 键 词：肺腺癌 HMLF方案 联合化疗 羟基喜树碱 氨甲蝶呤 5-氟脲嘧啶 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]