X刀治疗脑转移瘤临床疗效分析  

Clinical observation on 78 cases of brain metastases treated by X-knife.

作　　者：王伟[1] 张跃康[1] 雷町[1] 蔡博文[1] 毛伯镛[1] 

机构地区：[1]华西医科大学附属第一医院,四川成都610041

出　　处：《四川医学》2001年第7期612-613,共2页Sichuan Medical Journal

摘　　要：目的　探讨 X刀治疗脑转移瘤的临床疗效及剂量规划。方法　用 X刀治疗 78例脑转移瘤 ,其中单发 46例 ,多发 32例。总病灶数 146个。覆盖剂量 2 2 Gy(2 0～ 2 5 Gy) ,周边剂量 18Gy(14～ 2 0 Gy) ,随访 3～ 2 4月。结果　临床症状 ,体征明显改善者 6 9例 (88.5 % ) ,无变化 7例 (9% ) ,加重 2例 (2 .5 % )。肿瘤控制率为 92 % ,平均生存期 11月。结论　 X刀治疗脑转移瘤临床疗效显著 ,可延长晚期肿瘤病人的生存期 。Objective To explore the clinical effect and dose plans of the treatment for brain metastases by X knife.Methods Seventy eight patients with brain metastases were treated by X knife;of them,46 had single lesion and 32 had multiple lesions.There were 146 lesions in all.The median dose administered to the center and that to the margin of the tumor were 22Gy(20～25Gy)and 18Gy(14～20Gy)respectively.All patients underwent the follow up from 3 to 24 months.Results The clinical symptoms and signs were improved markedly in 69 cases(88.5%),remained unchanged in 7 cases (9%),and became worse in 2 cases(2.5%).The tumor control rate was 92%.The median survival time was 11 months.Conclusion The results demonstrate that X knife is an effective method for the treatment of brain metastases;it can prolong the survival period of patients and decrease the cranioencephalogenic mortality rate of malignant tumor cases.

关 键 词：脑转移瘤 X刀 放射治疗 生存期 疗效 

分 类 号：R730.55[医药卫生—肿瘤]