癌症患者血清中与Co^(2+)-反应的白蛋白的观察  

The Observation on Co^(2+)-reacted Albumin in Cancer Patient Serum

作　　者：章生艮 任惠民[1] 洪秀翎 张群华 王宝华[1] 

机构地区：[1]中国科学院上海生理研究所 [2]上海纺织工业局第三医院

出　　处：《基础医学与临床》1991年第4期39-42,共4页Basic and Clinical Medicine

摘　　要：经Co^(2+)处理而产生的Cp蛋白,在癌症患者血清中的含量明显低于正常血清中的含量。可以认为是一种能反映癌症的相关指数。本文证明了Cp的来源是白蛋白,它们的表现分子量分别为Cp_1≈130000、Cp_2≈110000道尔顿,接近自蛋白的一倍。Cp生成的适宜条件是偏于碱性溶液。本文还通过一批病例的检测数据,评阶了Cp含置作为癌症相关指数的意义。When serum was treated with Co2+-reagent, there appeared two ahbitional protein hands in the electrophoretic diagrams. These proteins have been denoted as Cp which means proteins comlementary to the 'abnormal proteins' presented in cancer sera whic are used as markers to distinguish cancer serum from normal serum. The apparent molecular weights ot Cp1 and Cp2 were found to be 130 000 and 110 000 Daltons respectively. Cp were proved to be partial converted products of serum albumin, by sectional gel treatment with Co2+-reagent and discontineous electrophoresis and/or by CN-Br polypeptide mapping tpchnique. The alkaline condition for Co2+ treatment was found to be proper and eassier for Cp producing and this implies that they are formed through chelating of albamins. It may be used as to checkout cancers. Through its application to clinic samples the method was being evaluated.

关 键 词：肿瘤 互补蛋白 白蛋白 钴离子 诊断 

分 类 号：R730.43[医药卫生—肿瘤]