去甲长春花碱联合顺铂治疗Ⅲ_b—Ⅳ期非小细胞肺癌疗效观察  

Navelbine plus cisplatin in the treatment of advanced non-small cell lung cancer

作　　者：任宏轩[1] 张灿珍[1] 赵玲[1] 

机构地区：[1]云南省肿瘤医院肿瘤内科,云南昆明650106

出　　处：《中国癌症杂志》2001年第3期241-242,共2页China Oncology

摘　　要：目的 :研究去甲长春花碱 (NVB) ,顺铂 (DDP)联合治疗Ⅲb—Ⅳ期非小细胞肺癌疗效 ,并与MVP方案作随机对照。方法 :NVB +DDP冶疗 16例 ,MVP组冶疗 2 0例。结果 :NVB +DDP组有效率 5 0 .0 % ,MVP组有效率40 .0 %。两组主要毒性反应为骨髓抑制和消化道反应。Ⅱ—Ⅳ度静脉炎发生率NVB +DDP组 (37.5 % )高于MVP组(0 .0 % ) (P <0 .0 1)。Ⅱ—Ⅳ度周围神经毒性发生率MVP组 (10 .0 % )高于NVB +DDP组 (0 .0 % ) (P >0 .0 5 )。结论 :NVB、DDP联合治疗非小细胞肺癌 ,有效率高 ,毒性可耐受 。Purpose:To evaluate the results of combination chemotherapy with navelbine (NVB) and cisplatin (DDP) in patients with stage Ⅲ b—IV non small cell lung cancer (NSCLC), as compared with MVP regimen. Methods:16 cases were treated with MVB+DDP, 20 cases were treated with MVP. Results:The response rate was 50.0% in patients with NVB plus DDP, 40% in those treated with MVP . The major toxic reactions in the two groups were tolerable,being myelo suppression and grstrointestinal reaction. Grade Ⅱ—Ⅳ phlebitis rate was 37.5% in patients with NVB puls DDP, 0.0% in those treated with MVP, respectively ( P <0.01). Grade Ⅱ—Ⅳ peripheral neuritis were observed 0.0% and 25.0%, respectirely ( P >0.05). Conclusions:A higher response rate is attainable with stage Ⅲ b—IV NSCLS treated by navelbine and cisplatin with tolerable toxicity. [

关 键 词：非小细胞肺癌 去甲长春花碱 顺铂 化疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]