诱导化疗加放射综合治疗局部晚期鼻咽癌的临床分析  

Clinical analysis of chemotherapy plus radiotherapy in locally advanced nasopharyngeal carcinoma

作　　者：王涛[1] 陈刚[1] 周云峰[1] 

机构地区：[1]武汉大学中南医院肿瘤放化疗科,武汉430071

出　　处：《中国癌症杂志》2001年第3期250-251,共2页China Oncology

摘　　要：目的 :探讨诱导化疗对局部晚期鼻咽癌放疗疗效的影响。方法 :96例Ⅲ、Ⅳ期鼻咽癌随机分为两组(化放组及单放组 ) ,每组 48例。放疗采用6 0 Co机或直线加速器照射鼻咽及颈部 ,鼻咽剂量DT 6 6— 76Gy 6 .5— 7.5周 ,颈部剂量DT 5 0— 70Gy 5— 7周。诱导化疗采用DDP +5 FU方案。结果 :化放组一、三、五年生存率分别为94.2 %、72 .9%、6 5 .7% ;单放组分别为 89.1%、5 6 .8%、46 .8% ,有显著性差异 (P <0 .0 5 )。化放组一、三、五年局控率各为 89.2 %、71.4%、6 3.9% ;单放组各为 82 .5 %、5 0 .1%、44 .2 % ,有显著性差异 (P <0 .0 5 )。化放组远处转移率为 2 0 .9% ,单放组为 41.7% ,两组比较有显著性差异 (P <0 .0 5 )。结论 :诱导化疗能提高局部晚期鼻咽癌放疗的局控率及生存率 ,降低远处转移。Purpose:To study the influence of chemotherapy on radiotherapy in locally advanced nasopharyngeal carcinoma. Methods:96 patients with histologically proven nasopharyngeal carcinoma in stages Ⅲ,Ⅳ were divided randomly into two groups. Radiotherapy group (48 cases) only received radiotherapy with DT66—76Gy in nasopharynx and DT50—70Gy in the neck. Chemoradiotherapy group (48 cases) received chemotherapy with cisplatin and 5 fluorouracil before the same radiotherapy as the radiotherapy only group. Results:The 1,3,5 year survival rates were 94.2%,72.9%,65.7% in chemoradiotherapy group and 89.1%,56.8 %,46.8% in radiotherapy group respectively, with significant difference between the two groups ( P <0.05). The 1,3,5 year local control rates in chemoradiotherapy group were 89.2%,71.4%,63.9% respectively in contrast to 82.5%,50.1%,44.2% respectively in radiotherapy group ( P <0.05). Distant metastasis rates were 20.9% in chemoradiotherapy group and 41.7% in radiotherapy group, respectively ( P <0.05). Conclusions:Chemotherapy plus radiotherapy can increase the survival rates and local control rates and decrease distant metastasis rates for locally advanced nasoharyngeal carcinoma. [

关 键 词：鼻咽肿瘤 放射治疗 化疗 综合治疗 

分 类 号：R739.63[医药卫生—肿瘤]