原发性骨恶性淋巴瘤临床病理及免疫表型观察  

Primary lymphoma of bone:A clinicopathologic and immunohistochemical observation

作　　者：王志华[1] 王晓秋[1] 方雪松[1] 牛俊扬[1] 程荣璇[1] 

机构地区：[1]安徽省立医院病理科,合肥230001

出　　处：《临床与实验病理学杂志》2001年第2期130-132,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :观察原发性骨恶性淋巴瘤 (PLB)的临床病理及免疫表型特征。方法 :对 8例PLB进行临床病理学观察及免疫组织化学染色 (ABC法 )。结果 :8例PLB平均年龄 5 1岁。X线片示溶骨性破坏或伴有骨质疏松 ;组织学观察均为弥漫性非霍奇金淋巴瘤 (NHL) ,大细胞性 4例、中心细胞性 2例、混合细胞性 (中心细胞 中心母细胞 )和淋巴浆细胞样各 1例 ;免疫组化显示B细胞 6例、T细胞 2例。结论 :PLB好发于 5 0岁左右 ,X线片主要表现为溶骨性破坏和骨质疏松。病理类型为弥漫性NHL ,细胞形态主要是大细胞 ,免疫表型则以B细胞多见。Purposes To observe the clinicopathologic and immunohistochemical features of primary lymphoma of bone(PLB). Methods Eight cases of PLB were investigated by light microscopy and immunohistochemical staining. Results The mean age of eight cases of PLB was 51 years. Radiographs of all cases showed the lytic lesions or osteoporosises; All the cases were diffuse non Hodgkins lymphomas(NHL), including 4 large cell lymphomas (centroblastic, CB), 2 centrocytic(CC), one mixed cell (CB CC ) and one lymphoplasmacytic (LP); Immunohistochemical features revealed 6 cases of B cell, 2 T cell. Conclusions The peak incidence for PLB is in the 5th decade with the radiologic appearance of lytic lesions or osteoporosises. All tumors are the diffuse NHL, including mainly large cell lymphomas and immunophenotypic features of B cell lymphomas. Immunohistochemistry is helpful in the differential diagnosis of PLB.

关 键 词：骨肿瘤 淋巴瘤 免疫组织化学 免疫表型 

分 类 号：R738.1[医药卫生—肿瘤]