口腔粘膜斑纹类疾病上皮异常增生状况调查分析  

A Research on the Correlation of Oral Mucosal Patches Stria Diseases and Epithelial Dysplasia

作　　者：陆志英 乐福媛[1] 

机构地区：[1]上海第二医科大学附属第九人民医院口腔医学院口腔内科,上海200011

出　　处：《上海口腔医学》2001年第2期102-104,共3页Shanghai Journal of Stomatology

摘　　要：目的　了解口腔粘膜常见斑纹类疾病与上皮异常增生之间的关系。方法　统计上海第九人民医院口腔粘膜科 30 6例口腔粘膜常见斑纹类疾病的上皮异常增生发生率 ,并比较几种常见口腔粘膜斑纹类疾病的上皮异常增生发生率 ;观察其中 30例作过 2次以上组织病理学检查的病例经过治疗后的发展趋势。结果　赤斑、白斑、扁平苔藓和盘状红斑狼疮的上皮异常增生发生率分别为 10 0 %、5 6 .43%、2 0 .83%和 13.6 4% ,经统计学分析 ,白斑和赤斑的上皮异常增生发生率明显高于扁平苔藓和盘状红斑狼疮 ;30例作过 2次以上组织病理学检查的病例中 ,轻度异常增生和中度异常增生的癌变率和逆转率无显著性差异。结论　支持白斑和赤斑为癌前病变 。Objective The aim of the present study was to elucidate the relationship between oral mucosal patches stria diseases and epithelial dysplasia . Methods Three hundred and six cases were studied, including one hundred and forty cases of leukoplakia , one hundred and twenty cases of lichen planus ,forty four cases of discoid lupus erythematosus and two cases of erythroplakia . The incidence of epithelial dysplasia in each kind of mucosal patches stria diseases were analyzed and compard. The developing tendency of 30 cases which underwent biopsy more than two times were analyzed and observed . Results In the common mucosal patches stria diseases ,the incidence of epithelial dysplasia in leukoplakia was 56.43% ,lichen planus was 20.83%, discoid lupus erythematosus was 13.64%, erythroplakia was 100%. The incidence of epithelial dysplasia were detected significantly more often in leukoplakia and erythroplakia than in lichen planus and discoid lupus erythematosus( P <0.05). Conclusion Leukoplakia and erythroplakia belong to premalignant lesion ,whether lichen planus belongs to premalignant lesion or not is controversial. [

关 键 词：口腔粘膜病 上皮异常增生 癌前病变 组织病理学 斑纹类疾病 

分 类 号：R781.5[医药卫生—口腔医学]