D4受体基因与精神分裂症的关联研究  

A study on the association between D4 receptor gene and schizophrenia

作　　者：江开达[1] 罗星光[1] 江三多[1] 杨晓敏[1] 张永华[1] 钱伊萍[1] 林嗣翠[1] 汤国梅[1] 汪栋祥[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《上海精神医学》2001年第2期63-66,共4页Shanghai Archives of Psychiatry

基　　金：卫生部科学研究基金资助(编号:96-2-140)

摘　　要：目的 探讨上海地区汉族人D4受体基因与精神分裂症的易感性、患者的性别、发病年龄、家族史以及症状严重度之间的关系。方法 抽取38例精神分裂症病人作研究,以76例正常人作对照。用聚合酶链式反应(PCR)扩增技术测定所有研究对象的D4基因型和等位基因。结果 发现D4受体基因与精神分裂症的易感性相关联,而与患者的性别、发病年龄、家族史以及症状严重度均无关联;发现正常对照组D4受体基因与性别相关联。结论 D4受体基因可影响精神分裂症患者的易感性,但不改变患者的发病年龄以及症状严重度,D4受体基因多态性的频率分布不受患者的性别及家族聚集性的影响,正常人群中D4受体基因多态性的频率分布存在性别差异。Objectives: To investigate the relationships between D4 receptor gene and the susceptibility to schizophrenia, the sex, age of onset, family history and severity of symptoms in these patients. Method: The genotypes and alleles of D4 receptor gene in 38 schizophrenic patients and 76 healthy controls were examined with PCR amplification technique. Results: There is an association between D4 receptor gene and the susceptibility to schizophrenia, but there are no associations between D4 receptor gene and the sex. age of onset, family history and severity of symptoms in these patients. There is an association between D4 receptor gene and the sex of healthy controls. Conclusion: Our findings suggest that D4 receptor gene may affect the susceptibility to schizophrenia, but can not change the age of onset and severity of symptoms in these patients. The frequency distribution of the polymorphism in D4 receptor gene is not influenced by the sex and the family history of the patients, but is different between the sexes of the healthy controls.

关 键 词：精神分裂症 D4受体基因 多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]