层粘素LN及其受体LN-R在胆管癌淋巴结转移中的作用  

Relationship between Laminin, Laminin Receptor and Lymph Node Metastasis of Cholangiocarcinoma

作　　者：李大江[1] 王曙光[1] 陈长宏[1] 陈莉[1] 王小丽[1] 

机构地区：[1]第三军医大学附属西南医院全军肝胆外科研究所,重庆市400038

出　　处：《中国肿瘤临床》2001年第5期351-353,共3页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(No39870830)

摘　　要：目的：探讨人胆管癌细胞中ＬＮ和ＬＮ—Ｒ的表达水平与胆管癌转移的关系。方法：应用 Ｓ—Ｐ免疫组化法 对５２例人胆管癌细胞中ＬＮ和 ＬＮ－Ｒ的表达水平进行研究。结果：ＬＮ及 ＬＮ－Ｒ高表达与胆管癌淋巴结转移至明显 相关， ＬＮ及 ＬＮ—Ｒ阳性肿瘤淋巴结转移率（８３％，５５％）明显高于ＬＮ—Ｒ阴性肿瘤（１５％，２０％，Ｐ＜０．０５），且ＬＮ及 ＬＮ—Ｒ 的表达与胆管癌组织学类型、分化程度亦存在明显相关（Ｐ＜０．０５）。结论：ＬＮ及ＬＮ—Ｒ的表达在胆管癌淋巴结转移中 的关系起联合作用。Objective: To study the correlation of the expression of Laminin (LN), laminin receptor (LN-R) with its biological behavior and lymph node metastasis of cholangiocarcinoma. Methods: The LN, LN-R protein expressions in 52 patients with cholangiocarcinoma were determined by using immunohistochemical method. Results: The positive expression rates of LN and LN-R protein of these patients were 38% and 42% respectively. There was significant difference observed among the different histopathological types and degree of differentiation of LN and LN-R (P<0.05). The metastatic rate of the tumors stained positively for LN and LN-R were obviously higher than those with negative LN and LN-R staining (P<0.05). Conclusion: It is suggested that the expression of LN and LN-R might play a significant role in lymph node metastasis in cholangiocarcinoma.

关 键 词：胆管癌 层粘素 层粘素受体 免疫组织化学 淋巴结转移 LN/LN-R 

分 类 号：R735.8[医药卫生—肿瘤] R73－37[医药卫生—临床医学]