米托蒽醌与阿霉素治疗中晚期非霍奇金淋巴瘤62例疗效对比观察  

Compared Mitoxantrone with Adriamycin in the Treatment for Advanced Non-Hodgkin's Lymphoma

作　　者：张应潮[1] 付显玉[1] 赵新[1] 尹绪德[1] 

机构地区：[1]四川省肿瘤医院,四川成都610041

出　　处：《肿瘤学杂志》2001年第3期171-173,共3页Journal of Chinese Oncology

摘　　要：[目的]研究米托蒽醌与阿霉素治疗非霍奇金淋巴瘤的疗效与毒副作用。[方法]随机将62例中晚期非霍奇金淋巴瘤患者分成两组 ,一组CNOP方案 ,以环磷酰胺(CTX)第1天静脉滴注650mg/m2 ,米托蒽醌(NVT)第1天静脉滴注10mg/m2 ,长春新碱(VCR)第1天静脉滴注1.4mg/m2,泼尼松(PDN)100mg/m2口服第1～5天 ,21天为1周期 ,连用4周期。另一组CHOP方案则用阿霉素(ADM)第一天静脉滴注50mg/m2,代替米托蒽醌(NVT) ,其余同CNOP方案。[结果]CNOP方案的有效率为66.7 % ,CHOP方案的有效率为62.62% ,P>0.05.两组主要毒性反应是骨髓似。CHOPⅠ度ECG异常18.5 % ;CNOP组无ECG改变 ,其Ⅰ度脱发占33.3% ;CHOP的Ⅰ、Ⅱ、Ⅲ度脱发分别为50%、28.1 %、21.9 % ,两组的差异有统计学意义(P<0.05)。[结论]米托蒽醌治疗非霍奇金淋巴瘤的疗效同阿霉素 ,但可降低毒副作用 ,提高患者生存质量。To study effect of mitoxantrone (novantrone,NVT) for non_Hodgkin's lyphoma (NHL).Sixty-two patients with advanced NHL were randomized into 2 groups ,one with CNOP regimen , another with CHOP regimen. Regimen CNOP consisted of CTX 650mg/m2 ,iv.d 1; NVT 10 mg/m2,iv.d1; PDN100mg/m2 PO.d 1～5 every 3 weeks for more than four cycles.ADM 50 mg/m2 replaced NVT 10mg/m2 in regimen CHOP .[Res28.1% and 21.9% respectively in CHOP group .There was significant difference with alopecia between 2 groups(P<0.05).[Conclusion]It demostrated that CNOP regimen is as effective as regimen CHOP in patients with advanced NHL. The side effects of mitoxantrone appeared less than those of adriamycin.

关 键 词：米托蒽醌 阿霉素 非霍奇金淋巴瘤 药物疗法 治疗 

分 类 号：R733.105[医药卫生—肿瘤]