p27^(Kip1)在宫颈癌中的表达及其临床意义  

Expression of p27^(Kip1) in Human Cervix Carcinoma and its Clinical Significance

作　　者：贺雅莉[1] 许双塔[1] 黄旭[2] 

机构地区：[1]福建医科大学附属第二医院,福建泉州362000 [2]福建医科大学附属协和医院,福建福州350000

出　　处：《肿瘤学杂志》2001年第3期178-179,共2页Journal of Chinese Oncology

摘　　要：[目的]研究子宫颈癌手术标本中p27Kip1 的表达在肿瘤预后判断中的临床意义。[方法]应用免疫组化SP法 ,检测宫颈癌手术标本中p27Kip1 的表达 ;[结果]p27Kip1 的表达与癌组织病理分期呈负相关 ,与肿瘤的预后呈正相关。[结论]子宫颈癌组织中 ,p27Kip1表达缺失的肿瘤组织恶性程度更高 ,并且直接影响肿瘤患者的术后生存期 ,是影响肿瘤预后的有效参考指标。检测癌组织中p27Kip1 的表达情况 ,有助于估计患者的预后 ,指导患者术后的综合治疗。To investigate the prognostic significance of p27Kipl expression in cervical carcinoma .Twenty samples of cervical mucosa and 80 samples of cervical carcinomas were analyzed by immunohistochemistry.The expression of p27Kip1was negatively related to the stage of cervix carcinoma(P<0.05),and positively related to the prognosis.[Conclusion]The reduction of the CKI p27Kip1 expression results in tumor cell escaped from inhibition of G1 to S transition of cell cycle.The tumor cell increases the ability of invasion and metastasis .The absence of p27kipl protein expression is a powerful negative prognostic marker in cervical carcinoma,and thereby may help to select patients benefiting from adjuvant therapy.

关 键 词：子宫颈肿瘤 P27^KIPL 免疫组织化学 预后 

分 类 号：R737.33[医药卫生—肿瘤]