CD44在某些皮肤肿瘤中表达的初步研究  

A preliminary study on the expression of CD44s in some skin tumors

作　　者：李远宏[1] 何春涤[1] 陈洪铎[1] 

机构地区：[1]中国医科大学第一临床学院皮肤科,110001

出　　处：《中国麻风皮肤病杂志》2001年第2期76-78,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　探讨CD44在皮肤肿瘤中的表达情况。方法 :　免疫组化法。结果 :　在鳞癌和基癌中 ,癌巢距表皮越近 ,CD44的表达越强 ;反之 ,CD44的表达越弱。在痣细胞痣和恶性黑素瘤 (恶黑 )标本中 ,CD44标准型 (CD44S)均表达。在其它皮肤肿瘤中 ,CD44的表达同正常皮肤。结论 :　在鳞癌和基癌中 ,CD44的表达与癌巢距表皮的远近有关。CD44S的表达与痣细胞的良性或恶性无关。Objective:To investigate the expression of CD44s in some skin tumors. Methods:Immunohistochemical method was used to detect the expression of CD44s, V4/5 and V6 in squamous cell carcinoma (SCC), basal cell carcinoma (BCC), mycosis fungoides (MF), Bowen's disease, malignant melanoma (MM), seborrheic keratosis, melanocytic naevus and normal skin.Results: In SCC and BCC the cancer nest was more nearer to the epidemis the expression of CD44s was more stronger. The expression of CD44s in MM and naevus was similar to that in SCC and BCC. In other skin tumors the expression of CD44s was as the same as the normal skin. Conclusion :The expression of CD44s was correlated with the location of the skin cancer nest and there is no association between the expression of CD44s and the malignancy of naevus cells. [

关 键 词：CD44S CD44V 皮肤肿瘤 表达 

分 类 号：R739.5[医药卫生—肿瘤]