咬合力丧失影响大鼠牙周组织中白细胞介素-6mRNA表达的研究  

Effects of Bite Force Loss on the Expression of IL-6 mRNA in Rat Periodontium

作　　者：袁林[1] 赵云凤[1] 周伟东[2] 

机构地区：[1]四川大学华西口腔医学院,,610041 [2]第一军医大学珠江医院

出　　处：《华西口腔医学杂志》2001年第3期152-154,共3页West China Journal of Stomatology

摘　　要：目的 :初探IL_6mRNA在牙周组织改建中的分子机理。方法 :选用Wistar大鼠建立正常咬合力、咬合力丧失的动物模型 ,采用原位杂交方法 ,观察牙周细胞中IL_6mRNA表达的动态变化。结果 :咬合力丧失引起牙周细胞中IL_6mRNA表达较正常咬合力时明显增强。结论 :咬合力丧失 ,促使IL_6mRNA明显增多 ,诱发了破骨过程 。Objective:The aim of this study is to evaluate the expression of IL_6 mRNA in rat periodontal cells under normal bite force and without bite force, and to explain periodontal remodeling from the molecular level. Methods:Animal models with normal bite force and without bite force were established by using Wistar rats. In situ hybridization technique was applied to detect changes of IL_6 mRNA expression in rat periodontal tissue. Results:Without bite force, the expression level of IL_6 mRNA increased significantly in periodontal cells. Conclusion:This study initially investigates the molecular mechanism of periodontal remodeling, and suggests that the histological morphology may be closely related to the mechanical stimulation.

关 键 词：咬合力 白细胞介素-6 mRNA 牙周组织改建 原位杂交 

分 类 号：R780.2[医药卫生—口腔医学]