胰腺癌 P53蛋白的表达与肿瘤生物学行为及预后的关系  

Expression of P53 in pancreatic carcinomas and the relation betweenthe biologic behaviour of tumors and its prognosis

作　　者：宋国炜[1] 金晓伟[2] 

机构地区：[1]吉林大学生物工程研究所,吉林长春130021 [2]长春市儿童医院

出　　处：《白求恩医科大学学报》2001年第4期377-378,共2页Journal of Norman Bethune University of Medical Science

摘　　要：目的 :探讨胰腺癌组织 P5 3蛋白的过度表达与肿瘤生物学行为及预后的关系。方法 :应用单克隆抗 P5 3抗体对 2 8例胰腺癌组织石蜡标本进行免疫组织化学染色。结果 :P5 3蛋白阳性物质位于肿瘤细胞核内 ,2 8例胰腺癌病例中有 16例 P5 3表达阳性 (5 7.1% ) ,与正常胰腺和癌旁组织比较 ,差异有显著性 (P<0 .0 5 ) ,且阳性率随分化程度的降低而升高 (P<0 .0 5 ) ,淋巴结转移阳性组表达率高于淋巴结转移阴性组 (P<0 .0 5 ) ,与术后存活情况有关 (P<0 .0 5 )。结论 :p5 3基因的异常表达在胰腺癌的发展过程中起重要作用 。Objective:To investigate the expression of P53 in pancreatic carcinomas and the relation between the biologic behaviour of tumors and its prognosis.Methods:Anti-P53 monoclonal antibody was used to stain pancreatic carcinoma tissue in immunohistochemistry.Results:Eleven cases of the pancreatic carcinomas were investigated 1 year after operation;the expression of P53 in 16 cases were positive,and the higher the tumor′s differentiation grades,the more the positive rate of P53 ( P <0 05).Conclusion:The results suggest that the abnormal expression of P53 is important in the process of pancreatic carcinoma development.

关 键 词：脂腺癌 P53基因 免疫组织化学 生物学行为 预后 

分 类 号：R735.9[医药卫生—肿瘤] Q786[医药卫生—临床医学]