薏苡仁酯对辐射诱导的人鼻咽癌细胞凋亡的促进作用  

The Enhancement of Radiation induced Apoptosis in Human Nasopharyng eal Carcinoma Cells by Coixenolide

作　　者：陈宁[1] 熊带水[1] 冯惠强[1] 李毓[1] 

机构地区：[1]广东省中医研究所,广东广州510095

出　　处：《华夏医学》2001年第3期257-259,共3页Acta Medicinae Sinica

基　　金：广东省中医药管理局资助项目 ( No.972 66)

摘　　要：目的 :探讨薏苡仁酯 (coixenolide,CXL )对辐射诱导的人鼻咽癌细胞 CNE- 2 Z凋亡的影响。方法 :以 6 0 Co为放射源 ,采用形态学 (荧光染色 )方法和流式细胞术观察 CNE- 2 Z细胞的凋亡和药物作用。结果 :CNE- 2 Z经照射后 ,凋亡细胞数增加 ,并与放射剂量和观察时间成正相关。加入 CXL,可使放射量效曲线和时效曲线左移。流式细胞仪分析也得到相似的结果。辐射也诱导正常细胞凋亡 ,但 CXL并没有加强此作用。结论 :CXL能选择性地促进射线所致的细胞凋亡。objective:To study the effect of coixenolide (CXL) on ind uc ed apoptosis of human nasopharyngeal carcinoma (NPC) cell line CNE 2Z by radiat ion.Methods:Cell apoptosis caused by γ ray was investigated with cell morpholo gy (fluorescence staining) and flow cytometry.Results:Apoptotic CNE 2Z cells in creased after radiation.CXL could shift the radiation dose and time response curves to the left.Similar result was obtained from flow cytometry.Irradiation a lso induced the apoptosis in normal mouse bone marrow cells,but,which was not in fluenced by CXL.Conclusion:CXL can selectively enhance the apoptosis induced by radiation.

关 键 词：鼻咽肿瘤 辐射诱导 细胞凋亡 薏苡仁酯 放射增敏 

分 类 号：R739.63[医药卫生—肿瘤]