结肠癌肝转移动脉灌注化疗与静脉化疗疗效评价  

Evaluation of Therapeutic Effect of Hepatic Arterial Infusion or Venous Chemotherapy in Treatment of Liver Metastasis from Colon Cancer

作　　者：蒋一鸣[1] 朱士驹[1] 蔡含[1] 奉典旭[1] 韩峰[1] 

机构地区：[1]上海市普陀区中心医院普外科,上海200062

出　　处：《同济大学学报（医学版）》2001年第2期27-28,共2页Journal of Tongji University(Medical Science)

摘　　要：目的　评价经肝动脉灌注化疗与静脉化疗治疗结肠癌肝转移的疗效。方法　 64例结肠癌肝转移患者随机分为肝动脉灌注化疗组和静脉化疗组。两组均采用FAM方案化疗。分析两组的CR、PR、RR及 1、2、3年生存率。结果　肝动脉灌注化疗组的CR、PR、RR显著高于静脉化疗组 ( 2 0 %vs.8.6% ,4 7.5 %vs.2 2 .3 % ,67.5 %vs.3 1.7% ,P <0 .0 5 ) ;肝动脉灌注化疗组的 1、2、3年生存率也显著高于静脉化疗组 ( 84 .4 %vs.2 1.9% ,5 9.4 %vs.6.3 % ,3 4 .4 %vs.0 % ,P <0 .0 5 )。Objective To evaluate the therapeutic effect of hepatic arterial infusion and venous chemotherapy in the treatment of patients with liver metastases from colon cancer.Methods Sixty four patients with liver metastases from colon cancer were randomly divided into hepatic arterial infusion (HAI) group and venous chemotherapy (VC) group. FAM chemtherapy protocol was used in both two groups. CR, PR, RR and 1 , 2 , 3 year survival rates in two groups were analyzed.Results CR, PR, RR in HAI group was significantly higher than that in VC group (20% vs. 8.6%; 47.5% vs. 22.3%; 67.5% vs. 31.7%, P <0.05, respectively). 1 ,2 , and 3 year survival rates in HAI group were also significantly higher than those in VC group (84.4% vs. 21.9%; 59.4% vs. 6.3%; 34.4% vs. 0%, P <0.05, respectively).Conclusion HAI was superior to VC group in the treatment of liver metastases from colon cancer.

关 键 词：结肠肿瘤 肝转移 肝动脉灌注 静脉化疗 

分 类 号：R735.35[医药卫生—肿瘤] R73－37[医药卫生—临床医学]