老年痴呆症转基因小鼠模型研究进展  

Advance on Research of Alzheimer Disease Transgenic Mice Model

作　　者：王玲玲[1] 奚涛[1] 沈子龙[1] 成国祥 

机构地区：[1]中国药科大学生物制药学院,南京210009 [2]上海市转基因研究中心,上海201300

出　　处：《药物生物技术》2001年第2期103-107,共5页Pharmaceutical Biotechnology

摘　　要：老年痴呆 (AlzheimerDisease ,AD)最明显的两个病理特征是蚀斑 (Plaque)和神经纤维团 (Neurofib rillaryTangle ,NFT)。现在发现与AD密切相关的基因有APP ,PSI ,PSII,apoE等基因。针对这些基因 ,研制了转基因小鼠 ,力图模拟临床病理情况 ,为疾病研究提供有益的模型。文章综述了这些转基因小鼠模型的基因构建及病理特征。The two most obvious pathologic features of Alzheimer Disease (AD) are plaque and Neurofibrillary Tangle (NFT).Some genes have been found to closely related to AD, such as APP,PSI,PSII and ApoE .To mimic clinical pathologic conditions and supply useful models for research , some transgenic mice models have been developed. In this article the gene construction and pathologic feature of these transgenic mice models are reviewed.

关 键 词：老年痴呆症 APP 转基因小鼠 蚀斑 神经纤维团 

分 类 号：R749.16[医药卫生—神经病学与精神病学]