含吡唑环的双杂环化合物的合成及其生物活性  

Synthesis of Pyrazolyl-heterocycles and Their Fungicidal Activities

作　　者：赵卫光[1] 陈寒松[1] 李正名[1] 韩玉芬[1] 颜寒[1] 赖俊英[1] 王素华[1] 

机构地区：[1]南开大学元素有机化学研究所,天津300071

出　　处：《高等学校化学学报》2001年第6期939-942,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金!重点项目 (批准号 :2 983 0 2 0 5 0 )资助

摘　　要：以 4 -硝基 -5-吡唑甲酰肼为起始物 ,合成了一系列含硝基的 5-吡唑基 -1 ,3 ,4 -二唑类、 5-吡唑基 -1 ,3 ,4 -噻二唑类和 5-吡唑基 -1 ,3 ,4 -三唑类的化合物 .初步生测结果表明A series of pyrazolyl heterocycles, including 1,3,4 thiodiazoles, 1,3,4 oxadiazoles and 1,3,4 triazoles were synthesized from 4 nitro pyrazole formhydrazide. The structures of all new compounds were confirmed by 1H NMR and elementary analysis. Their fungicidal activity was evaluated against Rhizoctonia solani. Structure activity relationships for the screened compounds were evaluated and discussed. It was found that some compounds showed a higher fungicidal activity and systematic activity.

关 键 词：吡唑 1 3 4-恶二唑 1 3 4-噻二唑 1 3 4-三唑 杀菌活性 双杂环化合物 合成 农药 

分 类 号：TQ450.11[化学工程—农药化工] O626.2[理学—有机化学]