9-咔唑-羧酸化合物的微波合成及其生物活性研究  

Studies on the Synthesis, Properties and Biological Activities of (9-Carbazoly)-carboxylic Acids

作　　者：劳文剑[1] 游静[1] 陆豪杰[1] 陈淑莲[1] 沈雪蛟[1] 欧庆瑜[1] 

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000

出　　处：《高等学校化学学报》2001年第6期955-957,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金! (批准号 :2 9870 5 3 3 )资助

摘　　要：This paper investigated a rapid one pot synthesis method of some substituted（9 carbazoly） carboxylic acids（3a3m）. The reaction was carried out by mixing of the 9H carbazoles derivatives with bromo esters and potassium hydroxide using DMF as solvent under microwave irradiation without catalyst. The optimized experiment conditions were 48 min irradiation time and 375 W microwave power. The required range of molar ratio of KOH to substituted carbazole was 35. The biological activities of some compounds have been tested. They have medium to weak antimicrobial activities.This paper investigated a rapid one pot synthesis method of some substituted(9 carbazoly) carboxylic acids(3a_3m). The reaction was carried out by mixing of the 9H carbazoles derivatives with bromo esters and potassium hydroxide using DMF as solvent under microwave irradiation without catalyst. The optimized experiment conditions were 4_8 min irradiation time and 375 W microwave power. The required range of molar ratio of KOH to substituted carbazole was 3_5. The biological activities of some compounds have been tested. They have medium to weak antimicrobial activities.

关 键 词：微波辐照 合成 抑菌活性 9-咔唑-羧酸化合物 生物活性 

分 类 号：O626.1[理学—有机化学] O621.392[理学—化学]