分子烙印聚合物固定相分离咖啡因和茶碱的研究  

Investigation of Separation of Caffeine and Theophylline on Molecular Imprinted Polymer Stationary Phases by High Performance Liquid Chromatography

作　　者：苏立强[1] 刘学良[2] 王俊德[2] 商振华[2] 

机构地区：[1]齐齐哈尔大学化工学院,齐齐哈尔161006 [2]中国科学院大连化学物理研究所,大连116012

出　　处：《高等学校化学学报》2001年第7期1122-1124,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 0 75 0 31)

摘　　要：Molecularly imprinted polymer(MIP) stationary phases against caffeine and against theophylline were prepared. Separation abilities of the phases were investigated by HPLC. The results showed that the theophylline based MIP stationary phase is highly selective to theophylline, and base lined separation of caffeine and theophylline was achieved. However, the caffeine based MIP stationary phase did not possess specific selectivity to the template molecule, caffeine. MIP with specific selectivity to template molecule can only be prepared when interactions between template and monomer go together.Molecularly imprinted polymer(MIP) stationary phases against caffeine and against theophylline were prepared. Separation abilities of the phases were investigated by HPLC. The results showed that the theophylline based MIP stationary phase is highly selective to theophylline, and base lined separation of caffeine and theophylline was achieved. However, the caffeine based MIP stationary phase did not possess specific selectivity to the template molecule, caffeine. MIP with specific selectivity to template molecule can only be prepared when interactions between template and monomer go together.

关 键 词：高效液相色谱 分子烙印聚合物 咖啡因 茶碱 固定相 分离 

分 类 号：O657.72[理学—分析化学] O658[理学—化学]