小剂量利培酮对首发精神分裂症的疗效观察  

Efficacy of very low dosage of risperidone in the treatment of first-episode schizophrenia

作　　者：吴天诚[1] 李永远[1] 李鸣[1] 颜维亚 顾永康[1] 汤臻[1] 李绍志[1] 唐英[1] 

机构地区：[1]江苏苏州市广济医院,215008

出　　处：《临床精神医学杂志》2001年第3期152-154,共3页Journal of Clinical Psychiatry

摘　　要：目的 :探索小剂量利培酮对首发精神分裂症的疗效和副反应。　方法 :33例患者给予小剂量利培酮 (A组 ) ,并以中等剂量的利培酮 (B组 ,34例 )和氯氮平 (C组 ,30例 )治疗进行对照。　结果 :A组第 8周末阳性和阴性症状量表 (PANSS)总分和各项目积分比疗前均显著下降 (P均 <0 .0 0 1) ;生效时间在第 2～ 4周 ,和 C组相似 ,但比 B组晚。疗程中 3组间 PANSS总分的减分率以及治疗后的总有效率均无显著差异。 A组的不良反应症状量表 (TESS)总分显著低于其它两组。　结论 :小剂量利培酮对首发精神分裂症是一种有效、安全、经济。Objective:To explore the efficacy and side effects of very low dosage of risperidone in the treatment of first-episode schizophrenia. Method:Compared with the patients treated with middle dosage of risperidone (group B,34 cases) and clozapine (group C,30 cases),33 cases (group A) were treated with very low dosage of risperidone. Results:The total scores and all factor scores of the positive and negative symptom scale (PANSS) in group A after 8 weeks decreased significantly (P<0.001).Group A took effects after 2~4 weeks,which was similar to that in group C,but later than that in group B.No differences were found in the reduction rates of PANSS scores and efficacy rates among 3 groups.Total scores of the treatment emergent symptom scale (TESS) were significantly lower in group A than in group B and C. Conclusion:It is suggested that very low dosage of risperidone is effective,safe,cheap and benefit in the treatment of first-episode schizophrenia.

关 键 词：利培酮 首发精神分裂症 疗效 副反应 治疗 

分 类 号：R749.305[医药卫生—神经病学与精神病学]