C-met在慢性肝病、原发性肝癌中的表达与意义  

EXPRESSIONS AND BIOLOGICAL SIGNIFICANCE OF C-MET ONCOPROTEIN IN CHRONIC LIVER DISEASES AND HEPATOCARCINOMAS

作　　者：刘平果[1] 王效民[1] 刘忠臣[1] 于仁祥[1] 

机构地区：[1]厦门市中山医院普外科,厦门361004

出　　处：《中国现代医学杂志》2001年第6期28-29,共2页China Journal of Modern Medicine

摘　　要：目的 :探讨原发性肝癌组织中C -met基因表达与临床病理关系。方法 :应用免疫组织化学方法 (ABC法 )检测 10例正常人肝组织 ,2 9例慢性肝病组织 ,37例原发性肝癌组织中C -met的表达。结果 :C -met阳性表达率在原发性肝癌 (5 1.4% )明显高于在慢性肝病 (0 )P <0 .0 5。原发性肝癌分化愈差 ,C -met阳性表达率愈高 (P <0 .0 5 )。C -met阳性表达病例 1年生存率明显低于其阴性表达的病例 (P <0 .0 5 )。C -met表达与肝癌的病理类型 ,肿块大小 ,HBsAg + / -均无关。结论 :C -met基因表达与原发性肝癌的浸润、分化有关 ,C -met过度表达有助区别肝良、恶性病变 ,在肝癌中其过度表达提示预后不良。Objective:To study the expression of c-met oncoprotein in hepatocarcinomas and it's relation to the clinical pathology.Methods:Using immunohistochemistry.The Positive rates of c-met oncoprotein and it's relation to the clinical pathology was evaluated in 37 cases hepatocarcinomas,29 cases chronic liver diseases,10 normal livers.Results:Positive rates of c-met was higher in hepatocarcinomas (51.4%) than in chronic liver diseases(0%)(P<0.05).The c-met expression rate decreased with the degree of the PHC differentiation.One-year survival rate was lower in cases with positive expressions of c-met than those with negative expressions of c-met(P<0.05).Expressions of c-met had no relation to PHC pathologic types and the size of tumors and HBsAg+/-.Conclusions:The expression of c-met might be related to hepatocarcinogenesis and hepatocarcinodifferentiation,overexpression of c-met in hepatocarinomas predict poor prognosis.Positive expression of c-met helps to differentiate malignant from benign hepatotumors.

关 键 词：癌基因蛋白 慢性肝病 肝脏肿瘤 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]