人肝病变组织低分子量角蛋白CK_(19)的表达  

Expression of Low Molecular Weight Cytokeratin 19 in Human Liver Lesions

作　　者：袁芳平[1] 黄培生[1] 高美钦[1] 龚华实[1] 

机构地区：[1]福建医科大学病理解剖学教研室,福州350004

出　　处：《福建医科大学学报》2001年第2期134-135,共2页Journal of Fujian Medical University

摘　　要：目的　研究低分子量角蛋白 CK1 9在人肝细胞癌、肝癌前病变、肝硬化组织中的表达状况及意义。　方法　采用免疫组织化学 SP法检测 5 6例肝细胞癌、8例肝硬化及 9例正常肝组织中 CK1 9的表达。　结果　 5 6例肝细胞癌组织中 2 6例 CK1 9表达阳性 ,显著高于对照组 (P<0 .0 0 1) ,癌组织 CK1 9多分布于腺样型或梁索型肝细胞癌。癌旁不典型增生组中异型增生细胞及卵圆细胞的 CK1 9表达率 (5 1.9% )显著高于癌旁非不典型组中肝细胞的表达率 (17.2 % ) ,但与肝癌组织的表达率差别不大。肝硬化组中 CK1 9的表达率为 37.5 % (3/ 8) ,阳性细胞均为卵圆细胞及异型增生细胞。　结论　肝细胞癌和增生的卵圆细胞及异型增生肝细胞表达 CK1 9,提示 CK1 9可做为判断肝细胞异型增生的一个指标。肝细胞癌 CK1 9表达与其组织学类型有密切关系。Objective\ To study the expression and significance of low molecular weight cytokeratin 19(CK19) in tissues of hepatocellular carcinoma(HCC), precancerous lesion and liver cirrhosis.\ Methods\ Using immunohistochemistry to detect CK\-\{19\} in 56 HCC, 8 liver cirrhosis and 8 normal liver tissues.\ Results\ Positive rate of CK19 in HCC was 46 4%(26/56), which was increased significantly compared with control group(P<0 001).\ CK19 was seen more frequently in adenoid\|type and cord trabecular\|type HCC.\ CK19 expression in both atypical hyperplastic liver cell and oval cell in dysplastic group which was similar to that in HCC was more frequently seen than that in non\|dysplasia group (P<0 05).\ Positive rate of CK19 in liver cirrhosis was 37 5% and CK19 was located in atypical hyperplastic liver cell and oval cell.\ Conclusion\ CK19 expression was seen in HCC, oval cell and atypical hyperplastic liver cell, which indicates CK19 can be used as a marker of atypical hyperplasia of liver cells.\ CK19 expression in HCC was closely associated with tissue types.\;

关 键 词：角蛋白 肝细胞癌 卵圆细胞 免疫组织化学 癌前病变 肝硬化 

分 类 号：R365[医药卫生—病理学]