注意缺陷多动障碍血儿茶酚胺与中医证候的关系分析  

Relationship of Plasma Norepinephrine and Epinephrine Level with TCM Syndrome Differentiation of Attention Deficit Hyperactivity Disorder: A Report of 80 Cases

作　　者：李宜瑞[1] 黄永强[1] 陈晓刚[1] 杨京华[1] 

机构地区：[1]广州中医药大学第一附属医院儿科,广州510405

出　　处：《广州中医药大学学报》2001年第2期118-120,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助课题!(编号 :97191)

摘　　要：【目的】 探讨注意缺陷多动障碍 (ADHD)患儿血儿茶酚胺水平及其与中医辨证分型的关系。【方法】采用高效液相色谱—电化学检测法 ,测定 80例ADHD患儿和 32例正常儿童的血浆去甲肾上腺素 (NE)、肾上腺素 (E)的浓度。【结果】ADHD患儿血浆NE、E水平高于正常对照组 (P <0 .0 1) ;中医辨证肾虚肝亢组NE、E水平与心脾两虚组间无显著性差异 (P >0 .0 5)。【结论】血浆NE、E水平之改变可能与ADHD患儿活动过多、冲动任性等临床症状的形成有关 ,而中医辨证肾虚肝亢证是否有交感神经兴奋的神经生化基础 ,有待进一步探讨。Objective To explore the relationship of plasma norepinephrine (NE) and epinephrine (E) level with TCM syndrome differentiation of attention deficit hyperactivity disorder (ADHD) in children. Methods Plasma NE and E levels in 80 ADHD children (Group A) and 32 normal volunteers (Group B) were measured by the method of high performance liquid chromatography_electrochemical detectio n (HPLC_ECD). Among 80 ADHD children, 49 were differentiated with kidney_yin def iciency and liver_yang hyperactivity syndrome (Group A 1) and 31 with heart_sp leen deficiency syndrome (Group A 2). Results Plasma NE and E levels in Gro up A we re higher than Group B (P< 0.01 ). The dif ferences of plasma NE and E levels in Group A 1 and Group A 2 were not signifi cant ( P> 0.05 ). Conclusion Hyperactivity and impulsi veness in ADHD children may be related with the high levels of plasma NE and E. The exc essively sympathetic excitement in ADHD with kidney_yin deficiency and liver_yan g hyperactivity syndrome is uncertain.

关 键 词：注意缺陷多动障碍 血液 儿茶酚腰 中医证候 肾阴虚 肝阳上亢 

分 类 号：R748[医药卫生—神经病学与精神病学] R277.78[医药卫生—临床医学]