Xp1区内定位注意缺损多动障碍易感位点的研究  

Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder

作　　者：江三多[1] 忻仁娥[1] 钱伊萍[1] 林嗣萃[1] 李飞[1] 吴晓东 汪栋祥[1] 汤国梅[1] 江开达[1] 

机构地区：[1]上海市精神卫生中心,200030 [2]Department of Anatomy and Neurobiology,Medical College of Ohio

出　　处：《中华医学遗传学杂志》2001年第3期169-172,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金!(39970 774)&&

摘　　要：目的　探讨注意缺损多动障碍 (attention deficithyperactivity disorder,ADHD)与单胺氧化酶 (monoamine oxidase,MAO) A型基因的遗传关系。方法　采用基于单体型相对风险 (haplotype- basedhaplotype relative risk,HHRR)和传递不平衡检验 (transmission disequilibrium test,TDT)的方法 ,在 6 0个 ADHD儿童和双亲中进行了 MAOCA微卫星多态性的关联和连锁分析。结果　经 HHRR和 TDT分析 ,ADHD儿童与 MAOCA位点 114bp相关联和连锁 (χ2分别为 4.90和 4.84,P<0 .0 5 )。结论　 ADHD与 MAO A型基因相关联和连锁 ,其易感位点可能定位于 Xp1区。Objective To detect the genetic relationship between monoamine oxidase(MAO) A type gene and attention deficit hyperactivity disorder(ADHD) in Chinese. Methods The haplotype based haplotype relative risk(HHRR) and the transmission disequilibrium test(TDT) methods were used to analyze the genetic association and linkage in 60 ADHD children and their parents. Results In this sample were found significant association ( χ 2=4.90, P <0.05) and linkage ( χ 2=4.84, P <0.05) between the MAOCA 114bp allele and DSM III R diagnosed ADHD in trios composed of father, mother and affected offspring. Conclusion The above results suggested that ADHD was associated and in linkage with MAO A gene, and the susceptibility loci might reside in chromosome Xp11 for ADHD.

关 键 词：注意缺损多动障碍 单胺氧化酶基因 关联 连锁 易感位点 遗传分析 儿童 

分 类 号：R346[医药卫生—基础医学]