自杀未遂与5-羟色胺2A受体基因的关联分析  

Association analysis of attempted suicide and 5-HT2A receptor gene

作　　者：曹莉萍[1] 李涛[1] 许珂[2] 刘协和[1] 

机构地区：[1]华西医科大学附属第一医院精神科,成都610041 [2]广州市精神病医院

出　　处：《中华医学遗传学杂志》2001年第3期195-197,共3页Chinese Journal of Medical Genetics

摘　　要：目的　探讨 5 -羟色胺 (5 - HT) 2 A受体基因 A- 1438G和 T10 2 C两种多态性与自杀未遂之间的关系。方法　以 149例自杀未遂者为研究对象 ,190名正常人为对照。采用聚合酶链反应 -限制性片段长度多态性 (polymerase chain reaction- restriction fragment length polymorphism,PCR- RFL P)方法 ,分析 5 -HT2 A受体基因 A- 1438G和 T10 2 C多态性。结果　 PCR- RFL P分析发现 ,男性自杀未遂与 5 - HT2 A受体基因 A- 1438G多态性的基因型 GG关联。结论　 5 - HT2 A受体基因 A- 1438G多态性可能与男性的自杀易感性相关。Objective: To examine the relationship of attempted suicide with A-1438G and T102C polymorphisms of 5-HT2A receptor gene. Methods: Genotypes and allele frequencies of A-1438G and T102C polymorphisms of 5-HT2A receptor gene in 149 attempted suicides and 190 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results: No differences in genotypes and allele frequencies of A-1438G and T102C polymorphisms of 5-HT2A receptor gene were observed between attempted suicides and the controls. However, an association between male attempted suicides and genotype (GG) of A-1438G polymorphism was found. Conclusion: These results suggested that liability to suicide behavior might be associated with A-1438G polymorpyhism of 5-HT2A receptor gene in male subjects.

关 键 词：自杀未遂 5-羧色胺2A受体基因 A-1438G多态性 T102C多态性 

分 类 号：R749.04[医药卫生—神经病学与精神病学]