大鼠急性牙髓炎症降钙素基因相关肽免疫反应性神经纤维的变化  

The change of calcitonin gene-related peptide immunoreactive nerve fibers in acute inflammatory pulpitis in rats

作　　者：曹志中[1] 刘军[1] 周中华[1] 叶晖[1] 唐卫忠[1] 

机构地区：[1]第二军医大学长海医院口腔科,上海200433

出　　处：《第二军医大学学报》2001年第5期459-460,共2页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金资助项目 ( 3 93 70 73 6)

摘　　要：目的 :观察大鼠降钙素基因相关肽免疫反应性 (CGRP- IR)神经纤维在大鼠急性牙髓炎症时的变化。方法 :结扎丝线法建立大鼠急性牙髓炎症模型和免疫组织化学技术观察牙髓 CGRP- IR神经纤维的变化。 结果 :急性炎症状态下 ,大鼠磨牙根髓 CGRP- IR神经纤维增粗、染色加重 ;而冠髓 CGRP- IR神经纤维减少 ,背景染色加重。 结论 :急性牙髓炎时牙髓内 CGRP增多 ,并在冠髓区向周围间质释放。Objective:To investigate the changes of calcitonin gene related peptide immunoreactive (CGRP IR)nerve fibers in rat dental pulps during acute inflammation. Methods: Rat acute pulpitis model was established by silk thread ligation and the change of CGRP IR nerve fibers was observed with immunohistochemical method.Results: In radical pulp,the CGRP IR nerve fibers became denser and more heavily stained;in the coronal pulp,the number of CGRP IR nerve fibers decreased,but the background staining was heavier. Conclusion: During acute inflammation,the amount of CGRP increases in dental pulps, and is released into the surronding tissue in a large scale in the coronal region.

关 键 词：急性牙髓炎 降钙素基因相关肽 免疫反应性 CGRP-IR 神经纤维 大鼠 

分 类 号：R781.31[医药卫生—口腔医学]