鼻咽癌患者鼻咽分泌物中肿瘤坏死因子α含量的临床观察  

Clinical observation of TNF-α content in nasopharyngeal secretion of patients with nasopharyngeal carcinoma

作　　者：崔德威[1] 赵玉兰[2] 邓玉丽[3] 罗国庆[1] 苏敏[2] 陈向阳[1] 

机构地区：[1]广东医学院附属医院耳鼻咽喉科,广东湛江524001 [2]广东医学院附属医院核医学科 [3]广东医学院第二附属医院检

出　　处：《临床耳鼻咽喉科杂志》2001年第5期202-203,共2页Journal of Clinical Otorhinolaryngology

基　　金：广东省医学科研基金资助项目! (No. A2 0 0 0 51 7)

摘　　要：目的 :探讨鼻咽癌患者鼻咽分泌物中肿瘤坏死因子 α(TNF- α)含量变化的临床意义。方法 :用特制装置收集 2 0例健康者和 5 2例鼻咽癌患者的鼻咽分泌物 ,应用放射免疫技术进行 TNF- α含量测定。结果 :对照组鼻咽分泌物中 TNF- α含量为 (12 .95± 4.6 2 ) pmol/ L,肿瘤组为 (33.6 8± 15 .13) pm ol/ L,肿瘤坏死组为 (6 4.0 0±11.5 7) pm ol/ L。肿瘤组含量明显高于对照组 ,其差异有极显著性意义 (P <0 .0 1) ;肿瘤坏死组含量进一步升高 ,与肿瘤组比较 ,其差异亦有极显著性意义 (P<0 .0 1)。结论 :鼻咽癌患者鼻咽分泌物中 TNF- α含量高于正常人 ,测定鼻咽分泌物中 TNF- α含量有助于鼻咽癌的诊断。Objective:To detect the changes of tumor necrosis factor α(TNF α) in nasopharyngeal secretion of patients with nasopharyngeal carcinoma(NPC).Method: The content of TNF α in nasopharyngeal secretion was determined by radioimmunoassay (RIA) in 20 controls,52 patients with NPC.Result:The average concentrations of TNF α were ( 12.95 ± 4.62 )pmol/L in control group,( 33.68 ± 15.13 ) pmol/L in NPC group and ( 64.00 ± 11.57 )pmol/L in NPC with necrosis group. The content of TNF α in nasopharyngeal secretion in control group was lower significantly than that of patients with NPC (P< 0.01 ).Conclusion:The level of TNF α in nasopharyngeal secretion of NPC patients was higher than that of normal subjects. To detect the content of TNF α in nasopharyngeal secretion is a useful test for the study and diagnosis of NPC.

关 键 词：鼻咽肿瘤 肿瘤坏死因子-Α 放射免疫测定 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]