大豆及丹贝异黄酮对乳腺癌、子宫癌和卵巢癌癌细胞的抑制效应  

Inhibition Effect of Soybean and tempeh Isoflavones on Human Breast,Uterus and Ovary Cancer Cells

作　　者：徐德平[1] 江汉湖[1] 汤涛[2] 肖凯[2] 

机构地区：[1]南京农业大学食品科技学院,210095 [2]中科院上海药物研究所,200031

出　　处：《食品科学》2001年第6期69-72,共4页Food Science

基　　金：国家自然科学基金资助项目(推准号:39470610)

摘　　要：用分离纯化的大豆和丹贝异黄酮的5个单位Genistein.Daidzein. Glycitein. Genistin . Daidzin分别作用于乳腺癌MCF－7细胞株、子宫癌Hela细胞株和卵巢癌HO－8910细胞株，研究各单位对各种癌细胞株的抑制率和IC_(50)值。结果Genistein在1.00E－04(mol/L)时对乳腺癌MCF－7细胞株抑制率为63％；IC_(50)=8.47E－05，对子宫癌Hela细胞株的抑制率为58.04％；IC_(50)IC50=9.45E－05，对卵巢癌HO－8910细胞株的抑制率为67.70％；IC_(50)=8.87E－05，Daidzein在1.00E－04(mol/L)浓度时对卵巢癌HO－8901细胞株的抑制率为67.70％；IC_(50)=2.62E－05。Tdoetermine Tempeh is oflavones inhibition on humabreast, uterus and ovary casncer cells. Thress cancer cells including MCF－7、Hela、Ho－8901 were treated by genistein、daidzein、glycitein、genistin、daidzin respectively, measuring the rate of inhibition and IC_(50). Genistein at 1.00E－04mol/L plrovided 63.08％rate of inhibition and IC_(50)IC50=8.47E－05 in breast cancer MCF－7 cell、58.042％rate of inhibition and IC_(50)=9.45E－05 in uterus cancer Hela cell、67.70％rate of inhibition and IC_(50)=8.890E－05 in ovary cancer HO－8910 cell, respectively. Daidzein at 1.00E－04mol/L produced 67.70％control and IC_(50)=2.62E－05 over ovary cancer HO－8910 cell.Tempeh isoflavone had higher antitumor activity than soybean isoflavone. Genistein showed has the higher control. Daindzein had effect only on ovary cancer cell. Genistin and Daidzintogethek showed no effect on three cancer cell.

关 键 词：异黄酮 癌细胞 抑制效应 大豆 防癌 乳腺癌 子宫癌 

分 类 号：R979.1[医药卫生—药品]