双氯芬酸钾缓释片的研制及释药特性的探讨  

Development of Diclofenac Potassium Sustained-Release Tablets and Exploration of Released Character

作　　者：宗莉[1] 王柏[1] 张宁[1] 

机构地区：[1]中国药科大学中昆药剂研究所,南京210009

出　　处：《中国药科大学学报》2001年第3期206-209,共4页Journal of China Pharmaceutical University

摘　　要：目的 :研制凝胶骨架型双氯芬酸钾缓释片 ,考察缓释片体外释药特性。方法 :以羟丙基甲基纤维素为主要凝胶材料 ,辅以疏水性阻滞剂以调节释放度 ,根据设计的体外释药速率 ,筛选处方。结果 :药物释放系扩散机理控制 ,释药速率受pH环境影响 ,不受压片压力的影响 ,受机械搅动影响较小。结论 :本文研制的双氯芬酸钾缓释片成型性好 ,具工艺重现性 。AIM\ Diclofenac potassium sustained release tablets were developed as a gel matrix for using twice daily and evaluated in vitro release characteristics. METHODS\ The formulations were screened according to the designed \%in vitro\% release rate by the use of HPMC as the gel matrix and the hydrophobic retarding agent to modify the release. RESULTS\ The release was properly characterized by the diffusion mechanism, influenced by pH of the media, slightly affected by the basket rotating speed, without the influences from the pressure exerted during the tabletting procedure. CONCLUSION\ The selected formulation of diclofenac potassium sustained release tablets could ensure the desired in vitro release rate. In addition, it proved a good manufacturing reproducibility.

关 键 词：双氯芬酸钾 缓释片 释放度 HPMC 非甾体消炎镇痛药 

分 类 号：R944[医药卫生—药剂学]