复方中药CCM-AT13抗胃癌SGC-7901细胞作用机制  

Antitumor effects and mechanism of a compound Chinese traditional medicine (CCM AT13) on human gastric cancer SGC 7901 cell line

作　　者：李永琦[1] 许才绂[1] 黄裕新[1] 赵国宁[1] 王庆莉[1] 

机构地区：[1]第四军医大学唐都医院消化内科,陕西西安710038

出　　处：《第四军医大学学报》2001年第9期835-837,共3页Journal of the Fourth Military Medical University

摘　　要：目的　研究科室自组复方中药 CCM- AT13对胃癌细胞及正常细胞的作用 .方法　与华蟾素、5 - FU对比 ,通过MTT法研究 CCM- AT13对胃癌细胞的杀伤作用 .结果　 10mg·L- 1 CCM- AT13,5 - FU与华蟾素的杀伤率分别为 (87.2± 3.3) % ,(34.5± 3.0 ) %与 (2 9.7± 1.7) % ,CCM- AT13具有较强的杀伤肿瘤细胞作用 ,杀伤率明显高于 5 - FU与华蟾素 ,而对人血管内皮细胞与大鼠血管平滑肌细胞杀伤作用较弱 .结论　 CCM- AT13抗肿瘤作用明显 。AIM To investigate the effects of a compound Chinese traditional medicine (CCM AT13) on gastric cancer cell and normal cells. METHODS MTT assay and cytocidal rate were employed. RESULTS Cytocidal rates of of CCM AT13, 5 FU and Huachansu at 10 mg·L -1 concentration were (87.2±3.3)%, (34.5±3.0)% and (29.7±1.7)% respectively. Cytocidal rate of CCM AT13 was markedly higher than that of 5 FU and Huachansu injection. CONCLUSION CCM AT13 has potent antitumor effects and great clinical value.

关 键 词：胃肿瘤 MTT 复方中药 CCM-AT13 抗癌作用 

分 类 号：R735.2[医药卫生—肿瘤] R730.52[医药卫生—临床医学]