少量多次输血对肝硬化并上消化道出血患者血液流变学的影响及临床疗效评价  

Effect of Frequent Small Hematometachysis on Blood Rheology in Patients with Hepatocirrhosis Accompanied by Hemorrhage of Upper Digestive Tract and Its Therapeutic Evaluation

作　　者：邵祥稳[1] 张庆华[1] 王秀卿[1] 

机构地区：[1]中国人民解放军第251医院,河北张家口075000

出　　处：《中国医师杂志》2001年第6期434-436,共3页Journal of Chinese Physician

摘　　要：目的　研究肝硬化上消化道出血患者血液流变学的改变 ,探讨出血控制后少量多次输血对其影响和临床意义。方法　对 34例肝硬化上消化道出血控制 10d后患者 ,每月给予 2 0 0ml鲜血 (或浓缩红细胞 2单位 ) ,分别于输血前和 3次输血后检测血液流变学的各项指标 ,观察肝功能和再出血时间 ,并与 33例对照。结果　治疗组全血比粘度、血浆比粘度、纤维蛋白原、红细胞压积较治疗前和对照组升高 ,血沉下降 ,ALT、AST、TBiL下降 ,A升高 ,再出血时间延长。结论　给肝硬化上消化道出血控制后患者少量多次输血 ,可以改变血液流变学 ,缓解病情 ,延长再出血时间间隔 。Object The purpose of this study was to analyze the changes in blood rheology in paitents with hepatocirrhosis accompanied by hemorrhage of upper digestive tract,explore the effect of frequent small bllod transfusion on it,after controlled hemorrhage and its clinical singnificance.Methods Thirty-four patients with hepatocirrhosis accompanied by hemorrhage of upper digestive tract were recruited into this study,10 days after controlled hemorrhage.These patients all underwent blood transfusion(200ml fresh blood or 2-unit concentrated erythrocyte) every month.Blood rheology data were obtained before and after 3 times blood transfusion,regular observed the liver function and further hemorrhage time interval.Results There were significantly elevation of whole blood specific viscosity(SV),blood plasma SV,fibrinogen,and hematocrit after treament,The frequent small blood transfusion led to reduce significantly in erythrocyte sedimentation,ALT,AST,TBiL,and significantly prolonged hemorrhage time interval further.Conclusions Frenquent small blood transfusion to patients with hepatocirrhosis could change the blood reology,remission illness state,prolongating the time interval of hemorrhage next occured.

关 键 词：肝硬化 上消化道出血 血液流变学 输血 治疗 

分 类 号：R575.2[医药卫生—消化系统]