海带多糖的免疫调节作用  

The immunomodulatory effect of polysaccharide from brown seaweed

作　　者：詹林盛[1] 张新生[1] 吴晓红[1] 王颖丽[2] 王之贤[1] 

机构地区：[1]军事医学科学院卫生学与环境医学研究所,天津300050 [2]解放军第88医院检验科,山东泰安271000

出　　处：《中国生化药物杂志》2001年第3期116-118,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家自然科学基金项目 (3 9770 64 4 )

摘　　要：目的观察海带多糖 (BSP)对正常及免疫低下小鼠免疫功能的影响。方法BSP经腹腔注射给药后 ,测定了各组小鼠胸腺、脾指数 ,外周血白细胞数 ,脾的T、B细胞增殖能力 ,脾细胞产生IL 2能力 ,以及血清和脾细胞溶血素含量等的变化。结果BSP 10 0mg/ (kg·d)× 10d能显著提高免疫低下小鼠胸腺、脾指数及外周血白细胞数 ,还能提高正常小鼠胸腺、脾指数 ;明显促进正常及免疫低下小鼠脾的T、B细胞增殖能力和脾细胞产生IL 2能力 ;BSP还能增加正常及免疫低下小鼠血清和脾细胞溶血素的含量。结论BSP是一种免疫调节剂 ,对正常及免疫低下小鼠的免疫功能具有促进作用。PurposeThe aim is to investigate the effects of BSP on immunological function in normal and immunosuppressed mices.MethodsThymus and spleen indexes, peripheral blood WBC number,the lymphocyte proliferation response, IL-2 production and serum and splenocyte hemolysin contents were measured after intraperitoneal injection of BSP in normal and immunosuppressed mices.Results(1)BSP 100 mg/(kg·d)×10d significantly increased the thymus and spleen indexes and peripheral blood WBC number in immunosuppressed mice.The thymus and spleen indexes in normal mice was also increased. In addition,BSP markedly improved T,B lymphocyte proliferation responses and IL-2 production in normal and immunosupressed mices.(2) BSP improved the serum and splenocyte hemolysin contents in normal and immunosuppressed mice. ConclusionIt was suggested that BSP was a kind of immunomodulator, and could improve the immunological function of normal and immunosuppressed mices.

关 键 词：海带多糖 免疫调节 淋巴细胞增值 白介素-2 溶血素 

分 类 号：R392－33[医药卫生—免疫学]