马蹄形肾并发肾细胞癌的胚胎发生学及诊治(附3例报告)  

Renal cell cancer in horseshoe kidney and the relationship between the abnormal renal development and tumorigenesis

作　　者：林涛[1] 魏强[1] 杨宇如[1] 李虹[1] 石明[1] 

机构地区：[1]华西医科大学附属第一医院泌尿外科,成都610041

出　　处：《临床泌尿外科杂志》2001年第6期250-251,共2页Journal of Clinical Urology

摘　　要：目的 :探讨马蹄形肾并发肾细胞癌的诊断与治疗 ,并结合胚胎发生学进展初步分析其发生的可能原因。方法 :回顾性分析 3例马蹄形肾并发肾细胞癌患者的临床资料并复习相关文献。结果 :3例均经手术和术后病理检查证实为马蹄形肾并发肾细胞癌。1例术后 3个月死于远处转移 ,另 2例术后至今已分别生存 3年和 2年 ,无复发。结论 :马蹄形肾并发肾细胞癌较罕见 ,诊断主要依靠影像学检查 ,治疗主要是行肾细胞癌根治加峡部切除术。峡部为实质的马蹄形肾来源于后生肾区域细胞的相互移行 。Purpose:To investigate the diagnosis and the treatment of renal cell carcinoma(RCC) in horseshoe kidney and evaluate the relationship between the embryology of the horseshoe kidney and tumorogenesis.Methods:Three cases of RCC in horseshoe kidney were presented with review of the literature of the embryology of the horseshoe kidney.Results:Radical nephrectomy was performed for all the 3 cases. 1 patient died of metastasis 3 months after surgery; the other 2 were free of tumor 1 year and 3 years postoperatively.Conclusions:RCC in horseshoe kidney is rare. The imaging techniques are essential to the diagnosis. Radical nephrectomy with resection of the isthmus is the main treatment method. Recently reported data suggest that the theory of a mechanical fusion is valid only for horseshoe kidneys with a fibrous isthmus. For the majority of horseshoe kidney with a parenchymatous isthmus,the embryological pathogenesis is considered as an abnormal migration of cells of the posterior nephrogenic area.This migration may be predisposed to the development of RCC.

关 键 词：肾畸形 马蹄形肾 胚胎学 并发症 肾细胞癌 

分 类 号：R691.1[医药卫生—泌尿科学] R737.11[医药卫生—外科学]