谷胱甘肽S-转移酶与膀胱癌关系的研究  

The study of the glitathione S transferase activity in blader cancer

作　　者：段建敏[1] 李智[1] 陈一戎[1] 秦大山[1] 

机构地区：[1]兰州医学院附属第二医院泌尿外科研究所,兰州730030

出　　处：《临床泌尿外科杂志》2001年第6期270-272,共3页Journal of Clinical Urology

摘　　要：目的 :探讨谷胱甘肽 S-转移酶 (GST)与膀胱癌的关系。方法 :检测 5 8例膀胱癌患者 (膀胱癌组 )、80例泌尿系非肿瘤患者 (泌尿系非肿瘤组 )和 40例正常对照者 (正常对照组 )血清中 GST活性及 2 4例膀胱癌患者癌组织、配对癌周正常组织和 13例正常膀胱组织中 GST活性。结果 :膀胱癌组血清中 GST活性明显高于泌尿系非肿瘤组和正常对照组 (P <0 .0 1) ,泌尿系非肿瘤组与正常对照组之间 GST活性差异无显著性意义 (P >0 .0 5 ) ,膀胱癌组癌组织中 GST活性明显高于癌周正常组织及正常膀胱组织 (P <0 .0 1) ,癌周正常组织与正常膀胱组织之间 GST活性差异无显著性意义 (P >0 .0 5 )。各级和各期膀胱癌之间血清中 GST活性及各级膀胱癌组织之间 GST活性差异均无显著性意义 (P >0 .0 5 ) ,而 ～ 期膀胱癌周组织中 GST活性较 期增高 (P <0 .0 5 )。结论 :膀胱癌患者 GST活性明显增高 ,GST活性在癌组织中随着癌分期的增高而增加 ,提示Purpose:To study the relationship between the glitathione S transferase and bladder cancer. Methods: The glutathione Stransferase GST) activity has been studied in serum of 58 bladder cancer patients,80 urinary non-tumor patients and 40 normal controls as well as in 27 cancer tissues,adjacent normal tissues and 13 normal bladder tissues.The grade and stage are classified according to the pathology. Results:The GST activity in serum of bladder cancer patients is much higher than that of non-tumor patients and normal control (P<0.001=. There is no difference of GST activity between non-tumor patients and normal controls. The GST activity in cancer tissues is significantly increased as compared with adjacent mormal tissues and normal controls (P<0.001=.There is no difference of GST activity between adjacent normal tissues and normal tissues. Among groups of different grade, the GST activity had no statistically differences either in serum or in cancer tissues.But the enzyme activity is increased in high stage (P<0.05. Conclusions:The results revealed a positive relation between the GST activity and the development of the bladder cancer as well as the malignant degree.

关 键 词：谷胱甘肽转移酶类 膀胱肿瘤 移行性细胞癌 

分 类 号：R737.14[医药卫生—肿瘤]