损毁大鼠双侧蓝斑引起多脏器出血  

BILATERAL LESION OF LOCUS COERULEUS IN RATS INDUCES HAEMORRHAGE IN MULTIPLE VISCERAL ORGANS

作　　者：王继江[1] 袁文俊[1] 杭建良[1] 王伟忠[1] 陈宜张[1] 

机构地区：[1]第二军医大学生理学教研室,上海200433

出　　处：《中国应用生理学杂志》2001年第2期121-124,共4页Chinese Journal of Applied Physiology

基　　金：国家"973"计划基金! (G2 0 0 0 5 6 90 5 );"九五"全军医药医学科学基金! (96M72 )资助课题

摘　　要：目的和方法 :用直流电损毁大鼠双侧蓝斑 ,观察膀胱及各内脏组织的出血性变化。结果 :完全损毁双侧蓝斑可恒定地引起严重的膀胱出血 ,并伴有其它脏器不规律性发生的充血或轻微出血。部分损毁双侧蓝斑亦可引起多脏器轻微的充血和出血 ,但膀胱出血不再恒定发生。切除肾上腺减轻应激反应 ,或应用组织胺H2 受体拮抗剂 ,对完全损毁双侧蓝斑引起的膀胱出血或其它脏器的组织学出血性变化无明显影响。结论 :损毁大鼠双侧蓝斑引起的多脏器出血并非由手术应激引起 ;也与组织胺H2 受体无关 ,其机制有待进一步研究。Aim and Methods: The haemorrhagic changes of the urinary bladder, as well as that of other visceral organs, were checked histologically in rats being received bilateral electrolytic lesion of the locus coeruleus (LC). Results: Complete lesion of bilateral LC constantly induced severe haemorrhage of the urinary bladder,accompanied with blood congestion or slight haemorrhage of other visceral organs.Partial lesion of bilateral LC also induced blood congestion or slight haemorrhage in multiple visceral organs, but the urinary bladder did not show haemorrhage change.Reduction of stress by adrenalectomy before lesion of the LC, or administration of antagonist of histamine H 2 receptor, had no obvious effect on the haemorrhage of the urinary bladder and histological changes of other visceral organs. Conclussion:These results indicate that the haemorrhagic change of multiple visceral organs induced by bilateral lesion of the LC in rats is not due to stress, or due to involvement of histamine H 2 receptor. The mechanism needs to be studied further.

关 键 词：蓝斑 电解损毁 大鼠 出血 血尿 多脏器出血 

分 类 号：R364.13[医药卫生—病理学] R363.271[医药卫生—基础医学]