C型钠尿肽的扩血管作用及机制  

THE VASODILATION AND ITS MECHANISM OF C-TYPE NATRIURETIC PEPTIDE

作　　者：王跃民[1] 裴建明[1] 朱妙章[1] 臧益民[1] 李明哲[1] 牛国保[1] 施溥涛 

机构地区：[1]第四军医大学生理学教研室,陕西西安710032 [2]上海生化研究所

出　　处：《中国应用生理学杂志》2001年第2期174-177,共4页Chinese Journal of Applied Physiology

摘　　要：目的和方法 :用常规离体血管灌流方法 ,观察钠尿肽家族新成员C型钠尿肽 (CNP)对家兔腹主静脉及腹主动脉的作用及其作用机制。结果 :CNP在 10 -10 ～ 10 -6mol/L浓度范围内对家兔静脉及动脉均呈剂量依赖性的舒张效应。其对静脉的作用与硝酸甘油 (NTG)相似 ,且扩血管作用无ANP强 ,以腹主动脉为对象分别施加阿托品(10 -7mol/L) ,酚妥拉明 (2 0 μg)或消炎痛 (2 0 μg)等均不影响CNP的舒血管作用 ,优降糖和心得安可明显降低CNP对腹主动脉的舒张作用。CNP在基础状态下提前加入不抑制NE的缩血管反应。结论 :CNP可能是一种静脉系统的扩张剂 ,同时亦是调节动脉张力的选择性调节肽 ,CNP舒血管作用机制至少有两途径 :一是与K+ ATP通道的开放有关 。Aim and Mcthods: With routine blood vessel perfusion in vitro , the vasodilation and its mechanism of C type natriuretic peptide, a new member of natriuretic peptide family were observed in rabbits.Results: CNP had the dose dependent vasorelaxing effects on abdominal artery and celeic vein at the range of 10 -10 10 -6 mol/L, its action on vein was just like nitroglycerin, its action on artery was weaker than that of ANP. Atropine (10 -7 mol/L), Regitine (20 μg),and indomethacin (20 μ g) had nothing effect on the vasodilation of CNP on abdominal artery. But glibenclamide (10 -6 mol/L) and propranlol (10 -6 mol/L) could decrease the vasodilation of CNP obviously, in addilion, CNP couldn't inhibit the vasoconstriction of NE. Conclusion:① CNP might be kind of venous systemic vasodilator,and it was also a aterial selective peptide controlling the vessel tone.② CNP dilated the vessel at least through two ways:(a) ATP sensitive K + channel,(b) β receptor.

关 键 词：C型利钠尿肽 心房利钠尿肽 血管舒张作用 

分 类 号：R972.4[医药卫生—药品] R965.2[医药卫生—药学]