胃癌雌孕激素受体的表达及临床意义  

The Expression and Clinical Singnificance of Estrogen Receptor and Progesterone Receptor of Gastric Cancer

作　　者：蒋勇[1] 黄书文[1] 张义胜[1] 卢林明[2] 

机构地区：[1]皖南医学院附属弋矶山医院急诊外科,241001 [2]皖南医学院附属弋矶山医院病理科,241001

出　　处：《皖南医学院学报》2001年第3期174-175,181,共3页Journal of Wannan Medical College

摘　　要：目的　探讨胃癌中雌激素受体 (ER)和孕激素受体 (PR)的表达和临床意义。方法　用免疫组化SP法对12 0例胃癌根治术后标本检测ER、PR。结果　①ER、PR在胃癌中阳性率分别为 32 .5 %、30 .8%,两者共同阳性2 8.3%;②ER、PR在胃癌中与Borrmann分型、组织学类型、淋巴结转移显著相关 (P <0 .0 1) ,而与患者年龄、性别、肿瘤部位无关 (P >0 .0 5 )。结论　ER、PR阳性表达的胃癌具有激素依赖性 ,测定胃癌中ER、PR对临床判定预后有意义。Objective To explore the expression and clinical significance of estrogen receptor (ER) and progesterone receptor (PR) in gastric cancer. Methods 120 gastric samples of gastrectomy were analyzed by immunohistochemistry (SP method) on ER and PR. Results ① The positive rates of ER and PR in gastric cancer were 32.5% and 30.8%,respectively and 28.3% was for all the two elements;② The positive rates of ER and PR were significantly related to Borrmann,histology type and metastasis of lymph nodes (P<0.01). There were no relations to age,sex or tumor position (P>0.05). Conclusion ER and PR positive gastric cancer has endocrine dependency.The determination of ER and PR of gastric cancer is significant in deciding clinical prognosis.

关 键 词：胃肿瘤 雌激素受体 孕酮受体 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]