转化生长因子-α表皮生长因子受体在上颌窦鳞癌表达的研究  

Study on the Expression of TGF-α,EGFR in Human Maxillary Sinus Squamous Cell Maxillary Sinus Carcinoma

作　　者：陈东[1] 贺建业[1] 魏永昆[1] 许平[1] 高冬玲[1] 张红[1] 宋一民[1] 

机构地区：[1]河南医科大学一附院病理科,郑州450052

出　　处：《肿瘤防治研究》2001年第4期264-266,共3页Cancer Research on Prevention and Treatment

基　　金：河南省科委自然科学基金资助项目(9740 2 45 0 0 )

摘　　要：目的　探讨表皮生长因子受体 ( EGFR)和转化生长因子 -α( TGF-α)在上颌窦鳞癌发生的不同阶段中的表达情况。方法　应用免疫组化 LSAB法。结果　 TGF-α、EGFR在上颌窦粘膜不典型增生病变、鳞癌及乳头状瘤癌变组的阳性表达率明显高于正常、单纯增生粘膜及乳头状瘤病变组 ( P<0 .0 5) ;TGF- α与 EGFR在上颌窦癌中的表达有明显的相关关系 ( P<0 .0 5) ;二者的阳性表达与患者的性别、年龄、肿瘤组织的分化程度 ( P>0 .0 5) ,而与淋巴结转移及患者的生存期有关 ( P<0 .0 5)。结论　 TGF- α、EGFR在上颌窦癌发生发展中起重要作用 ,联合检测二者 。Objective To assess the changes and possible role of expression of TGF α and EGFR in maxillary sinus carcinogenesis.Methods Immunohistochemical study using LSAB kit. Results The positive rates of TGF α and EGFR in maxillary sinus dysplasia hyperplastic epithelia,squamous cell carcinoma and papilloma with cancerous were significantly higher than that in normal and simple hyperplastic epithelia and papilloma.( P <0.05)TGF α had a close relationship to EGFR,meanwhile,there was significant correlation between the two factors( P <0.05).The expression of TGF α and EGFR did not correlate with sex,age,histologic grading( P <0.05),but that is correlated significantly with lymphnode metastasis and the survival stage(3 years)( P <0.05).Conclusion The increased expression of TGF α and EGFR may play an important role in the process of carcinogenesis in maxillary sinus squamous cell carcinoma and be used as a useful marker for the assessment of biological behavior and prognosis of maxillary sinus squamous cell carcinoma.

关 键 词：转化生长因子-Α 表皮生长因子 上颌窦肿瘤 鳞癌 

分 类 号：R739.62[医药卫生—肿瘤]