p21^(WAF1/CIP1)在原发性肺癌中的表达  

The Expression of p21^(WAF1/CIP1) in the Primary Lung Cancer

作　　者：张旃 李清泉[2] 杨炯[2] 

机构地区：[1]广东省177医院二内科,广州510317 [2]湖北医科大学附属第一医院呼吸内科

出　　处：《肿瘤防治研究》2001年第4期281-283,F002,共4页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨 p2 1 WAF1/ CIP1在肺癌中的生物学功能。方法　用免疫组化法检测 62例肺癌和 1 4例正常肺组织石蜡切片 p2 1 WAF1/ CIP1的染色强度。结果　 1 .p2 1 WAF1/ CIP1定位于细胞核或细胞浆。2 .小细胞肺癌与非小细胞肺癌中核 p2 1 WAF1/ CIP1表达存在显著性差异 ( P<0 .0 0 5) ,浆 P2 1 WAF1/ CIP1则不存在显著性差异 P<0 .0 0 5)。3.核与浆 P2 1 WAF1/ CIP1表达的对比在高、低分化肺癌中具有显著性差异 P<0 .0 5)。结论　肺癌细胞 p2 1 WAF1/ CIP1的生物学功能可能依其定位。Objective To explore the biological function of p21 WAF1/CIP1 in the lung cancer.Methods p21 WAF1/CIP1 expression was immunohistochemically analyzed in paraffin embeded sample from 76 patients with surgically resected and fiberoptic bronchoscopy biopsy lung diseases,including 62 lung cancer samples and 14 normal lung tissue samples.Results 1.p21 WAF1/CIP1 was located either in the cell nuclear or in the cell plasma.2. Not plasma but nuclear p21 WAF1/CIP1 expression was significantly different between SCLC and NSCLC,while neither of them was correlate with other clinical parameter of lung cancer.3.Nuclear p21 WAF1/CIP1 /plasma p21 WAF1/CIP1 was related to the differentiation of lung cancer. Conclusion The biological function of nuclear p21 WAF1/CIP1 and plasma p21 WAF1/CIP1 may depended on their site,quantities and histologic tumor classification of lung cancer.

关 键 词：P21^WAF1/CIP1 肺肿瘤 原发性肺癌 病理 基因表达 

分 类 号：R734.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]