药物对5-羟色胺引起的犬离体大隐静脉收缩作用的影响  

Effects of Plant Alkaloid on 5- Hydroxytryptamine Induced Vasoconstriction of Dog Saphenous Vein

作　　者：章新华[1] 邢军[1] 王怀良[1] 

机构地区：[1]中国医科大学基础医学院临床药理学教研室,沈阳110001

出　　处：《中国医科大学学报》2001年第4期241-242,250,共3页Journal of China Medical University

基　　金：国家科技部重点资助项目 ;96 90 1 0 5 2 74

摘　　要：目的 :探讨植物药生物碱 94 95 10L对犬离体大隐静脉 5 HT1like受体的作用。方法 :建立 5 羟色胺 ( 5 HT)对犬离体大隐静脉收缩作用的量效曲线 ,观察 94 95 10L对该量效曲线的影响。结果 :94 95 10L表现出对 5 HT1like受体的微弱的激动作用 (α =2 8.0 % ) ,其 10 -5mol·L-1和 3× 10 -5mol·L-1均使 5 HT量效曲线下移 ,并使最大收缩高度分别下降至 ( 81.0± 3 .2 ) %和 ( 72 .3± 11.7) %。结论 :94 95 10L对犬离体大隐静脉 5 HT1like受体有部分激动作用 ,该作用对防治偏头痛发作可能有重要意义。Objective: Our aim was to identify the effects of plant alkaloid 94 95 10 L on 5 HT 1 like receptors of dog saphenous vein. Methods: The cumulative concentration effect curves of 5 hydroxytryptamine (5 HT) on isolated saphenous vein of dogs in the presence or absence of 94 95 10 L was investigated. Results: The 94 95 10 L behaved as a weak 5 HT 1 like receptor agonist (α=28.0 %). The 94 95 10 L shifted the 5 HT induced concentration effect curve to the right in a concentration dependent manner with a depressed maximal efficacy (81.0%±3.2 % and 72.3%±11.7% respectively). Conclusion: The 94 95 10 L might be a partial agonist of 5 HT 1 like receptor, and this effect is similar to that produced by the novel anti migrain medicine sumatriptan.

关 键 词：5-羟色胺 5-羟色胺1like受体 大隐静脉 偏头痛 防治 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]