前部增生性玻璃体视网膜病变引起慢性低眼压房水生成率的测定  

Testing of aqueous humor flow rate in chronic hypotony following anterior proliferative vi- treoretinopathy

作　　者：刘百臣[1] 张卯年[2] 刘铁城[2] 彭秀军[1] 赵玉兰[3] 廖杰[3] 

机构地区：[1]海军总医院眼科,北京100037 [2]解放军总医院眼科,北京100853 [3]解放军总医院医学仪器中心

出　　处：《军医进修学院学报》2001年第2期144-146,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的 :探讨前部增生性玻璃体视网膜病变 (anteriorproliferativevitreoretinopathy,aPVR)低眼压状态下房水生成率变化 ,从房水动力学的角度揭示aPVR引起慢性低眼压的发病机制。方法 :利用培养的同种兔皮肤成纤维细胞制作aPVR引起慢性低眼压的动物模型。于术前及术后不同时间点分别观测眼压 ,术后 14d、2 8d、5 6d分别以高效液相色谱仪测量房水荧光素清除率 ,进一步计算房水生成率。结果 :术后 2周、4周、8周实验组平均眼压、房水生成率明显低于对照组 (P <0 0 5或P <0 0 1)。结论 :在aPVR病理状态下 。Objective:To study the aqueous humor flow rate in chronic hypotony by anterior proliferative vitreoretinopathy (aPVR), and to demonstrate physiologic mechanisms of the hypotony. Methods:Model of hypotony following aPVR was made by cultured homologous rabbit dermal fibroblasts on pigmented rabbits. The intraocular pressure (IOP) was examined preoperatively and on days 7, 14, 28 and 56 postoperatively. The rate of fluorescein diminished in the aqueous humor was tested postoperatively, and the aqueous humor flow rate was calculated. Results:The average IOP of experimental group was lower than that of control group on days 14, 28 and 56 significantly ( P <0 01), and the flow rate of aqueous humor in experimental group reduced remarkably. Conclusion:The hypotony in aPVR was associated with decreased aqueous humor flow rate.

关 键 词：增生性玻璃体视网膜病变 眼房水 低眼压 αPVR 

分 类 号：R774.12[医药卫生—眼科] R775[医药卫生—临床医学]