多发性硬化患者糖皮质激素受体含量与疗效的关系  

A study of the relationship between of the contents of glucocorticoid receptors in multiple sclerosis patients and the efficacy of steroid therapy

作　　者：李森美[1] 郑璇[1] 巫顺秀[1] 魏丽玲[1] 庄伟端[1] 陈显光[1] 许楚芸[1] 

机构地区：[1]广东汕头大学医学院附属第一医院神经科,515041

出　　处：《中国实用内科杂志》2001年第5期282-283,316,共3页Chinese Journal of Practical Internal Medicine

基　　金：广东省卫生厅科研基金资助!(编号A2000445)

摘　　要：目的　探讨多发性硬化（ＭＳ）患者外周血白细胞糖皮质激素受体（ＧＲ）含量与糖皮质激素的治疗效果关系。方法用放射免疫法和放射配体结合法测定２５例ＭＳ患者的血浆皮质醇（Ｆ）含量和血白细胞ＧＲ含量。结果ＭＳ患者血浆Ｆ含量与正常对照组无明显差异，而血ＧＲ含量为（８６３５±１４３２）位点／细胞，明显高于正常对照组（５３２０±５４０）位点／细胞（Ｐ＜０．０１）。用常规大剂量激素治疗时，治疗前ＧＲ位点数高者［（９３５６±６４５）位点／细胞共１８例］，疗效优于位点数低者［（６１７６±３８５）７例］。结论ＭＳ患者外周血白细胞ＧＲ增多，ＧＲ含量高者近期疗效较好，ＧＲ含量低者可加用超大剂量激素治疗，以提高疗效。Objective To explore the relationship between the contents of glucocorticoid receptors(GR) in multiple sclerosis(MS) patients and the efficacy of steroid therapy. Methods Radio - immunological method and radioligand combination were used to determine the contents of plasma cortisol(F) and the GR contents of blood corpuscles of 25 MS cases. Results No obvious difference was found between the F contents of plasma between the group of patients and the normal control group of normal subjects whereas the GR contents in the blood of the former with (8635±1432 ) sites/cell were significantly higher than those of the control group with (5320 ±540) sites/cell(P < 0. 01 ). 18 patients with high - figure GR (9356 ± 645 ) sites/cell prior to treatment showed better therapeutic effects than the 7 patients with low - figure GR (6176 ±385 ) sites/cell. Conclusions Better therapeutic effects can be achieved in cases of increased blood corpuscle GR of external factors and high GR contents. Those of low GR contents may be given hormotherapy with larger doses to enhance results.

关 键 词：多发性硬化 受体 糖皮质激素 MS 

分 类 号：R744.51[医药卫生—神经病学与精神病学] R977.11[医药卫生—临床医学]