阿霉素乙基纤维素微球肝动脉栓塞化疗的实验研究  

HEPATIC ARTERIAL CHEMOEMBOLIZATION OF ADRIAMYCIN- ETHYLCELLULOSE MICROSPHERES IN THE TREATMENT OF LIVER CANCER IN RATS

作　　者：彭方兴[1] 严律南[1] 林琦远[1] 白绍槐[2] 张旋波[2] 

机构地区：[1]华西医科大学附属第一医院肝胆胰研究室 [2]华西医科大学实验动物中心

出　　处：《中国普外基础与临床杂志》2001年第3期138-140,共3页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金资助(批准号:39770723)

摘　　要：目的观察阿霉素乙基纤维素（ＡＤＭ－ＥＣ）微球经大鼠肝动脉化疗栓塞对肿瘤生长及自然生存期的影响。方法 ＡＤＭ－ＥＣ经肝动脉插管注射治疗 Ｗｉｓｔａｒ大鼠 Ｗ２５６移植性肝癌，实验共分 ５组： Ｉ组（对照组）、 Ⅱ组（注射生理盐水组）、Ⅲ组（注射盐酸阿霉素组）、Ⅳ组（注射空白乙基纤维素（ＥＣ）微球组）及Ⅴ组（注射ＡＤＭ－ＥＣ 微球组）。结果ＡＤＭ－ＥＣ组的肿瘤生长抑制程度、坏死程度及荷瘤自然生存期显著优于其它各组。结论经肝动脉注射ＡＤＭ－ＥＣ微球可抑制肿瘤生长，促进肿瘤坏死，延长生存期，从而大大提高肿瘤化疗的疗效。Objective To investigate the growth of tumors and the natural life length of the rats after the adriamycin-ethylcellulose microspheres (ADM- EC mc) were injected in the rats bearing transplantable liver cancer through their hepatic arteries. Methods ADM-EC me were infused into the proper hepatic arteries of the Wistar rats (W256). All of the rats were divided randomly into five groups, group 1: control, group 2: normal saline, group 3: conventional ADM, group 4: placebo ethylcellulose microspheres, and group 5: ADM-EC mc. Results As compared with other four groups, the ADM-EC mc (group 5) showed the best inhibition of the growth of tumors and the longest mean life length of the rats. Conclusion Hepatic arterial infusion of ADM-EC mc can inhibit the growth of the tumor, aggravate the necrosis, and improve the effects of the chemotherapy of liver cancer.

关 键 词：化疗栓塞 肝癌 阿霉素 乙基纤维素微球 大鼠 实验 

分 类 号：R735.7[医药卫生—肿瘤] R73－361[医药卫生—临床医学]