一氧化氮与青光眼患者眼压升高关系的研究  

A clinical investigation on the relationship between nitric oxide and elevation of intraocular pressure in glaucoma

作　　者：韩瑶[1] 张斌[1] 郭秀锦[1] 张增群[1] 

机构地区：[1]河北医科大学第二医院眼科,石家庄050000

出　　处：《中华眼科杂志》2001年第4期281-283,共3页Chinese Journal of Ophthalmology

摘　　要：目的　探讨一氧化氮 (nitricoxide ,NO)在青光眼患者眼压升高中的作用。方法　对急性闭角型青光眼患者 16例 ,老年性白内障患者 2 9例 ,正常志愿者 30例 ,应用高效液相色谱分析仪检测其血浆和房水中NO的含量 ,并以NO2 和NO3 之和表示。结果　正常对照组血浆中NO的平均含量为(2 96 9 37± 86 2 85 )ng/L ;青光眼组血浆中NO的平均含量为 (1390 78± 30 2 95 )ng/L ,较对照组明显降低 (t=2 85 3 ,P <0 0 1) ;白内障组血浆中NO的平均含量为 (4 2 34 89± 1495 2 3)ng/L ,较对照组明显升高。对照组房水中NO平均含量为 (140 5 83± 6 0 2 70 )ng/L ;青光眼组房水中NO的平均含量为(2 0 5 2 0 3± 6 94 74)ng/L ,与对照组比较差异无显著性 (t=1 86 2 ,P >0 0 5 ) ;白内障组房水中NO的平均含量为 (2 45 4 6 7± 6 5 5 13)ng/L ,较对照组明显升高。房水 /血浆NO含量比值 :对照组为 47 3% ,白内障组为 5 8 0 % ,二者的比值差异无显著性 ;而青光眼组为 144 0 %。结论　血浆、房水中NO含量与急性闭角型青光眼眼压升高有关。Objective To investigate the role of nitric oxide (NO) in the process of intraocular pressure (IOP) elevation in glaucoma. Methods The levels of NO in plasma and in aqueous humor which were obtained from 16 patients with acute angle closure glaucoma (10 female, 6 male), 29 cases with cataract (13 female, 16 male) and 30 normal volunteers (13 female, 17 male) were detected by high performance liquid chromatography and expressed with the total NO 2 and NO 3. Results It was found that the mean level of NO in the plasma in glaucoma group was (l 390 78± 302 95) ng/L that was significantly lower than that in the normal group (2 969 37± 862 85) ng/L ( t =2 853, P <0 01). But in cataract group it was (4 234 89± 1 495 23) ng/L that was significantly higher than that in the normal group ( t =4 471, P <0 01). There was no significant difference in the level of NO in the aqueous humor between glaucoma group (2 052 03± 694 74) ng/L and normal group (1 405 83± 602 70) ng/L ( t =l 862, P >0 05). But in cataract group the mean level of NO (2 454 67± 655 13) ng/L in the aqueous humor was increased remarkably in comparison with that in the normal group ( t =2 752, P <0 01). The rate of the mean content of NO in normal aqueous humor and plasma (aqueous/plasma) was 47.3%, and that in cataract group, 57 96% ( P >0 05). But in glaucoma group, the rate was 144.0%. Conclusion The content of nitric oxide in the plasma and aqueous humor is related to the elevation of IOP in cases with acute angle closure glaucoma.

关 键 词：一氧化氮 青光眼 眼内压 

分 类 号：R775[医药卫生—眼科]